坎地沙坦对高血压并阵发性心房颤动患者脑利钠肽及超敏C反应蛋白的影响

Effect of Candesartan on High- Sensitive C- Reactive Protein and Brain Natriuretic Peptide in Patients with Hypertension Combined with Paroxysmal Atrial Fibrillation

目的探讨坎地沙坦对高血压合并阵发性心房颤动患者血浆脑利钠肽(BNP)及超敏C反应蛋白(hs-CRP)的影响。方法将60例原发性高血压合并阵发性心房颤动患者分为研究组(坎地沙坦治疗组)和对照组(非洛地平治疗组),各30例。结果研究组房颤的复发次数明显少于对照组,复发持续时间亦明显短于对照组(P<0.05);研究组BNP和hs-CRP水平均较治疗前明显下降,左心房内径(LAD)较治疗前明显减少(P<0.05)。结论坎地沙坦能降低高血压合并阵发性心房颤动患者血浆BNP及hs-CRP水平,抑制心房重构,降低复发率。

Objective To investigate the effect of candesartan on high- sensitive C- reactive protein（ hs- CRP） and brain natriuretic peptide（ BNP） in hypertensive patients combined with paroxysmal atrial fibrillation（ AF）. Methods 60 casess of hypertensive patients with paroxysmal atrial fibrillation were randomly divided into the study group（ n = 30, treated with candesartan）, and the control group（ n = 30, treated with felodipine）. Results The atrial fibrillation recurrence frequency in the study group was significantly lower than that in the control group（ P 〈 0. 05）; The paroxysmal atrial fibrillation duration time in the study group was also significantly shorter than that in the control group（ P 〈 0. 05）. After treatment,the level of plasma BNP and hs- CRP in the study group were significantly lower than those before treatment（ P 〈 0. 05）,while the level of plasma BNP and hs- CRP in the study group showed no statistically significant difference with those before treatment. The LAD in the study group was significantly diminished compared with that before treatment,while the LAD in the control group showed no significant difference with that before treatment. Conclusion For hypertensive patients with paroxysmal atrial fibrillation,candesartan can reduce the plasma BNP and hs- CRP levels,and inhibit left atrial remodeling,and is effective to decrease the recurrence of paroxysmal atrial fibrillation.