2013年至2014年医院痛风患者用药情况与生活质量分析

Analysis of Drug Use in the Gout Database and the Life Quality of Patients during 2013- 2014

目的探讨医院痛风数据库中常用药物使用情况并分析患者生活质量,为临床治疗提供参考。方法利用医院痛风数据库收集患者资料,选取医院2013年11月至2014年11月住院接受抗痛风药物治疗的340例痛风患者,统计并分析其抗痛风类药物的用药情况,用药频度（DDDs）、排序,以及其他分类药品非甾体抗炎药、激素类药、抗酸药在痛风各分期的使用分布情况;统计并分析患者治疗前及治疗后（出院时）视觉模拟评分（VAS）、健康相关生活质量量表（HRQOL）评分情况。结果抗痛风类药使用中,秋水仙素DDDs最高,使用率达85.29%,高于其他药物的使用率（P〈0.01）;在治疗痛风其他分类药品中,抗酸药碳酸氢钠使用率69.41%最高,与非甾体抗炎药物使用率45.59%及激素类药物使用率22.35%相比,差异均有统计学意义（P〈0.01）,且碳酸氢钠在痛风各个分期均有使用,除在急性发作期与非甾体抗炎药使用率差异不明显外（P〉0.05）,在间隔期、慢性期、缓解期的使用率均高于其他分类药物（P〈0.05）。通过治疗,患者的疼痛评分及生活质量评分均有明显改善。治疗后,重度疼痛患者所占百分率降低37.06%,生活质量评分达81~100分患者百分率上升27.16%,与治疗前患者所占比例相比,差异均有统计学意义（P〈0.01）。结论该院治疗痛风疾病,以秋水仙碱联合非甾体抗炎药作为急性发作期治疗的一线药物,在慢性期及缓解期主要应用排酸剂及抑酸剂,碳酸氢钠作为抗酸药在各个分期用于对症治疗,用药基本合理,临床疗效佳,患者的生活质量得到明显改善。

Objective To explore the use of drugs in the hospital and to analyze the quality of life of patients,in order to provide reference for clinical treatment. Methods The data of 340 cases of gout patients treated with anti- gout drugs in the hospital from November 2014 to November 2013 were selected using database of gout patients in hospital,statistics and analysis of gout patients with anti- gout drug medication, DDDs（ DDDs）, sorting, and the distribution of other drugs such as non- steroid body anti- inflammatory drugs, hormone drugs antacids in different gout stages were performed; the VAS, HRQOL scores of patients before treatment and after treatment（ discharge） were analyzed. Results In the anti- gout medicine usage, colchicine DDDs was the highest with the drug use rate 85. 29%,which was significantly higher than the use of other drugs rate（ P 〈 0. 01）. In the treatment of gout other drug classification, antacid bicarbonate utilization was 69. 41%, and compared with the non- steroidal anti- inflammatory drug use rate of 45. 59%and hormone drugs use rate of 22. 35%,the difference had statistical significance（ P 〈 0. 01）; it was used in every stages,and only in the acute phase it showed no significant difference（ P 〉 0. 05）; in the interval,the chronic phase,the remission period of the use rate were higher than other drugs（ P 〈 0. 05）; through the treatment, the patient ’ s pain score and life quality score were significantly improved. After treatment,the percentage of patients with severe pain was reduced by 37. 06%,the quality of life score reached 27. 16%（ P 〈 0. 01）. Conclusion The treatment of gout disease by colchicine combined with non- steroidal anti- inflammatory drugs are used as the first- line treatment of acute exacerbation,and in chronic phase and remission stage, the main application of acid and acid inhibitor are appllied. Sodium bicarbonate as antacids is used in various stages for symptomatic treatment. The drug use is reasonable,the clinical curative effect is good,the life quality of the patient improves obviously.