摘要
目的：探讨18 F-FDG PET／CT显像对原发性肺淋巴上皮瘤样癌（ LELC）的诊断价值。方法回顾性分析沈阳军区总医院2006年1月至2014年3月间19例临床怀疑原发性肺LELC患者的18 F-FDG PET／CT影像、胸部增强CT及临床资料，其中男10例，女9例，平均年龄56．4岁。通过研究病灶18 F-FDG PET／CT及胸部增强CT影像学特点，结合SUVmax、18 F-FDG摄取类型、病理类型及临床分期，评估18 F-FDG PET／CT显像对原发性肺LELC的诊断价值。采用两样本t检验和单因素方差分析处理数据。结果18 F-FDG PET／CT显像诊断原发性肺LELC的灵敏度为12／13，特异性为4／6；原发性肺LELC SUVmax与肺其他恶性肿瘤及良性病变相比，差异有统计学意义（ F＝3．67， P＜0-05）。在不同分期中，Ⅳ期原发性肺LELC与Ⅰ、Ⅱ、Ⅲ期相比，病灶直径大、密度低、SUVmax高（ F＝7．01， P＜0．05）。放射性摄取环形增高的病灶SUVmax（3．94±0．67）较其他3种类型高（2．86±0．35；t＝4-07， P＜0．05）。 Schmincke型 SUVmax（3．61±0．71）较 Regaud型 SUVmax高（2．76±0．29；t＝2．99，P＜0-05）。结论18 F-FDG PET／CT显像对原发性肺LELC具有较高的诊断价值。
Objective To assess the diagnostic value of 18 F-FDG PET/CT imaging for primary pul-monary lymphoepithelioma-like carcinoma （LELC）. Methods A total of 19 patients （10 males, 9 fe-males;average age 56.4 years） with suspected primary pulmonary LELC undergone whole-body 18F-FDG PET/CT and chest contrast CT scan were enrolled in this retrospective study. The SUVmax and uptake pat-terns of FDG, the histological types and the clinical stages were recorded. Image characteristics of contrast CT and FDG PET/CT were observed, and the diagnostic efficiency was calculated. Two-sample t test and one-way analysis of variance were used to analyze the results. Results The diagnostic sensitivity and spe-cificity of LELC were 12/13 and 4/6 for FDG PET/CT. The SUVmax of LELC lesions was significantly differ-ent from that of other lung malignant tumors or lung benign lesions （F=3.67, P〈0-05）. The lesion had longer diameter, lower CT density, higher SUVmax in stage Ⅳ patients, compared with that in stageⅠ-Ⅲpatients （ F=7.01, P〈0.05） . The significant difference of SUVmax was found between lesions with ring up-take and lesions with other uptake types （3.94±0.67 vs 2.86±0.35; t=4.07, P〈0-05）. The SUVmax was higher in Schmincke tumors when compared with that in tumors of Regaud subtype （ 3. 61 ± 0. 71 vs 2. 76 ± 0-29; t=2.99, P〈0.05） . Conclusion 18 F-FDG PET/CT could be an accurate method in differential diag-noses of primary pulmonary LELC.
出处
《中华核医学与分子影像杂志》
CAS
北大核心
2015年第6期438-441,共4页
Chinese Journal of Nuclear Medicine and Molecular Imaging
