Sirt1基因的研究进展

Research progression of Sirt1

Sirtuins家族成员之一,Sirt1(Sirtuin type1)是依赖于烟酰胺腺嘌呤二核苷酸(NAD+),在体内与多种组蛋白和非组蛋白为底物,通过去乙酰化作用来调节其活性的一种组蛋白脱乙酰酶。广泛参与调控哺乳动物细胞寿命的信号及糖代谢、胰岛素分泌等多条代谢通路,对代谢综合征、细胞凋亡、心血管疾病和神经退行性疾病等发挥重要的作用。Sirt1可作为治疗不同疾病的靶点逐渐被人们所重视。

A member of the conserved sirtuin family, Sirtl （Sirtuin typel） is a NAD＋ dependent protein deacetylase, which has been shown to deacet）late a wide range of non-histone substrates and histone substrates to regulate their activities. Therefore, Sirtl is characteristically involved in the regulation of several crucial cellular signal pathways in- cluding different signal pathways to regulate mammalian lifespan, glueoneogenesis and insulin secretion and so on. It has been reported that Sirtl extensively participate in the occurrence of metabolic syndrome, cell apoptosis, cardiovascular disease, neurodegenerative diseases and so on. In a word, Sirtl could be emphasized as a new therapy target for many different diseases.