尿微量白蛋白检测在高血压性脑出血患者早期肾损害中的诊断价值

Value of urinary albumin detection in the prevention of renal damage in patients with hypertensive cerebral hemorrhage

目的探讨尿微量白蛋白检测在高血压性脑出血患者早期肾损害中的诊断价值。方法将江西省永新县人民医院2013年1月-2015年1月收治的60例高血压性脑出血患者设为观察组,另选择健康体检者60例作为对照组。测定两组对象的尿常规、肌酐、尿素氮以及尿微量白蛋白,观察两组发生肾损害的比例。结果观察组与对照组血肌酐、血尿素氮均在正常范围内,两组比较差异无统计学意义（P〉0.05）;观察组尿微量白蛋白较对照组明显升高,差异有统计学意义（P〈0.01）;血、尿β2-微球蛋白、尿微量白蛋白单项指标阳性率及肾多项指标联检总阳性率均高于尿常规和肌酐、尿素氮总阳性率,差异有统计学意义（P〈0.01）;对照组尿微量白蛋白阳性2例,阳性率为3.3%,观察组尿微量白蛋白阳性32例,阳性率为53.3%,两组比较差异有统计学意义（P〈0.01）。结论尿微量白蛋白是诊断肾功能早期损害的敏感指标,对高血压性脑出血患者早期防范肾损害有重要的意义。

Objective To investigate the diagnostic value of urinary albumin in the early renal damage in patients with hypertensive cerebral hemorrhage. Methods 60 cases of hypertensive cerebral hemorrhage treated in the People＇s Hospital of Yongxin County in Jiangxi Province from January 2013 to January 2015 were set as the observation group.60 cases of healthy physical examination as the control group.The urine routine,creatinine,urea nitrogen and urinary albumin were determined in two groups. Results Observation group and control group of blood creatinine and blood urea nitrogen had difference no statistical significance（P〈0.05）,but microalbuminuria in the observation group was significantly higher than that in the control group,there was a statistically significant difference（P〈0.01）; single index positive rate of blood and urine beta 2-microglobulin,urine microalbumin and multiple indexes inspection total positive rate was higher than that of total positive rate of the routine urine and creatinine,urea nitrogen,there was a statistically significant difference（P〈0.01）;microalbuminuria positive in control group were 2 cases,positive rate was 3.3%,and that were 32 patients in observation group with the positive rate was 53.3%,there was a statistically significant difference（P〈0.01）. Conclusion It is very important for the early prevention of renal damage in patients with essential hypertensive cerebral hemorrhage.