唑来膦酸联合放疗治疗肺癌骨转移的临床效果

Clinical effect of zoledronic acid combined with radiotherapy in treating bone metastases from lung cancer

目的探讨唑来膦酸联合放疗治疗肺癌骨转移的临床效果。方法选取我院2012年3月-2014年12月收治的肺癌骨转移患者80例作为研究对象,将其随机分为两组,每组40例,对照组患者给予唑来膦酸治疗,观察组患者在对照组的基础上给予放射治疗,分别对两组患者的临床疗效（疼痛缓解情况、生存质量改善情况等）进行比较,并了解其治疗期间的不良反应发生情况。结果观察组和对照组患者治疗后的疼痛缓解率分别为90.0%和72.5%,生存质量总改善率分别为87.5%和62.5%,观察组显著优于对照组,差异有统计学意义（P〈0.05）,观察组不良反应发生率显著高于对照组,差异有统计学意义（P〈0.05）。结论采用唑来膦酸联合放疗治疗肺癌骨转移的临床效果较好,疼痛缓解率较高,有利于患者生存质量的改善,是比较理想的治疗方法,值得临床推广应用,但需对治疗中合并的不良反应发生情况进行积极的防治。

Objective To explore the clinical effect of zoledronic acid combined with radiotherapy in treating bone metastases from lung cancer. Methods 80 patients with bone metastases from lung cancer from March 2012 to December 2014 of our hospital were selected.Patients were divided into two groups and each group was 40 cases.Patients in control group was given zoledronic acid and patients in observation group was given radiotherapy on the basis of control group.Clinical effect liked pain relief and life quality improvement in two groups were compared.The incidence of adverse reaction was understood during treatment. Results The pain relief rate in observation group and control group was90.0% and 72.5% respectively,the total improvement rate of life quality was 87.5% and 62.5% respectively.Both of that in observation group were better than control group,and the difference was statistical significance（P〈0.05）.But the incidence rate of adverse reactions in observation group was obvious higher than that of the control group,and the difference was statistical significance（P〈0.05）. Conclusion Using zoledronic acid combined with radiotherapy has good clinical effect for bone metastases from lung cancer and with high pain relief rate.It is helpful to improve the life quality of patients.It is an ideal treatment method and is worth to popularize in clinical.But the incidence of adverse reaction during combined treatment should be give positive control.