二丁酰环磷腺苷钙联合硝酸异山梨酯治疗稳定型心绞痛的疗效观察

Curative effect observation of calcium dibutyryladenosine cyclophosphate combined with dinitrosorbide treating stable angina cordis

目的探讨二丁酰环磷腺苷钙联合硝酸异山梨酯治疗稳定型心绞痛的效果。方法选取2013年1月-2015年1月我院心内科收治的115例稳定型心绞痛患者作为研究对象,随机分为观察组和对照组。两组患者入院均给予抗血小板聚集、降脂药物等对症治疗,对照组54例在此基础上给予硝酸异山梨酯治疗,观察组61例在对照组基础上加用二丁酰环磷腺苷钙,总疗程为1个月。疗程结束后比较两组的临床疗效、心电图效果、心绞痛发作次数、发作间期以及不良反应发生率。结果观察组的临床总有效率以及心电图总有效率与对照组比较明显升高（P〈0.05）;观察组的心绞痛发作次数明显减少,发作间期延长,与对照组比较,差异有统计学意义（P〈0.05）;两组药物的不良反应发生率差异有统计学意义（P〈0.05）。结论二丁酰环磷腺苷钙联合硝酸异山梨酯治疗稳定型心绞痛的效果肯定,值得临床广泛应用。

Objective To explore the effect of calcium dibutyryladenosine cyclophosph-ate combined with dinitrosorbide treating stable angina cordis. Methods 115 patients with stable angina cordis received by department of cardiology in our hospital from January 2013 to January 2015 were selected as study group and they were divided into observation group and control group.Patients in two groups on admission were given the symptomatic treatment such as antiplatelet aggregation and lipid-lowering drug and so on,on this basis,control group（54 cases） was treated by dinitrosorbide,while observation group was given calcium dibutyryladenosine cyclophosph-ate on the basis of control group.The total treatment course was a month,after treatment,the curative effect,the effect of electrocardiogram,attack frequency of angina pectoris,attack interval and incidence rate of adverse reaction between two groups was compared respectively. Results Clinical total effective rate and the total effective rate of electrocardiogram was obviously improved compared with control group（P〈0.05）.Attack frequency of angina pectoris in observation group was obviously reduced,attack interval was prolonged,and there was a statistical difference compared with control group（P〈0.05）.There was a statistical difference of incidence rate of adverse reaction between two groups（P〈0.05）. Conclusion The effect of calcium dibutyryladenosine cyclophosph-ate combined with dinitrosorbide treating stable angina cordis is definite.It is worthy of clinical wide application.