培美曲塞或紫杉醇同步放疗治疗老年局部晚期肺腺癌临床观察

Clinical Effect of the Pemetrexed or Paclitaxel Synchronous Radiotherapy for Treating the Elderly Patients With Locally Advanced Lung Cancer

目的 探究培美曲塞或者紫杉醇同步放疗治疗老年局部晚期肺腺癌的临床效果。方法 选取2013年2月~2015年2月收治的老年局部晚期肺腺癌患者76例,随机分为两组,各38例。对照组和观察组分别给予紫杉醇、培美曲塞同步放疗治疗,对比两组临床治疗有效率、不良反应情况。结果 两组临床疗效相比,差异不具有统计学意义（P〉0.05）;观察组脱发、中性粒细胞减少等不良反应少于对照组,差异具有统计学意义（P〈0.05）。结论 培美曲塞或者紫杉醇同步放疗治疗老年局部晚期肺腺癌均具有临床效果,而培美曲塞同步放疗治疗不良反应较少。

Objective To investigate clinical effect of the pemetrexed or paclitaxel synchronous radiotherapy for treating the elderly patients with locally advanced lung cancer. Methods We selected 76 cases of elderly patients with locally advanced lung adenocarcinoma,received by our hospital in February 2013 to February 2015,they were randomly divided into two groups,38 cases respectively. Control group and observation group were given paclitaxel and pemetrexed synchronous radiation treatment,and then we compared clinical effectiveness and adverse reactions of the two groups. Results Clinical curative effect of two groups were compared,and there was no significant difference（P 0.05）,in the observation group,alopecia,neutropenia and other adverse reactions were significantly less than that of the control group. And the difference was obvious（P 0.05）. Conclusion Clinical effect of pemetrexed or paclitaxel synchronous radiation in treatment of the elderly with locally advanced lung adenocarcinoma is significant and pemetrexed synchronous radiation therapy has less adverse reactions.