摘要
肠道菌群对人体能量代谢、肠道功能、免疫系统、治疗糖尿病等方面具有重要作用。肠道定植真菌菌群虽在肠道菌群中所占比例极少,但对肠道菌群内稳态平衡的维持作用显著。真菌菌群不仅通过细胞壁上的多种抗原复合物激活人体先天性和获得性免疫反应,而且还参与促进肠系膜和肠道周围免疫淋巴系统的成熟,涉及多系统性疾病(如肠易激综合征、消化性溃疡、肿瘤、乙型肝炎、侵袭性肺炎和冠状动脉粥样硬化症等)的病理生理过程。肠道真菌菌群在肠道疾病中的重要作用正逐渐得到关注。以下将对其在菌群失调相关性腹泻和炎性肠病中的关键作用作一综述。
The abnormal intestinal fungal community has been associated with multisystem diseases,such as antibiotic-associated diarrhea（ AAD）,inflammatory bowel disease（ IBD） and atherosclerosis et al. But compared to the bacterial community,the knowledge regarding to fungal community is still limited. The fungal community is rare in whole microflora while it does matter to maintain the balance of gut microflora. It participates in many nature and nurture immunoreactions,promotes the mature of mesenteric and mucosal immune system. In this review,special attention were paid to the effect of abnormal fungal community in antibiotic-associated diarrhea and inflammatory bowel disease.
出处
《肠外与肠内营养》
北大核心
2015年第6期378-381,共4页
Parenteral & Enteral Nutrition
关键词
真菌菌群
肠道微生物
炎性肠病
菌群失调相关性腹泻
Fungal community
Intestinal microflora
Inflammatory bowel disease
Antibiotic-associated diarrhea
