颅底与非颅底脑膜瘤增长率的Meta分析

Growth rate of skull base and non-skull base meningiomas： a meta analysis

目的 评价颅底与非颅底脑膜瘤增长率的差异.方法 在线检索有关脑膜瘤增长情况随访的研究文献,对符合条件的研究用Review Manager（5.3版）软件进行分析.结果 （1）共纳入7篇符合要求的观察队列研究,包括未经处理的脑膜瘤患者361例.（2） Meta分析结果显示,颅底与非颅底脑膜瘤的绝对增长率（年）、相对增长率（年）、倍增时间（月）差异有统计学意义[WMD =0.42,95％CI（0.20,0.64）,P =0.0002;WMD=1.05,95％ CI（0.82,1.29）,P＜0.01;WMD=-0.55,95％CI（-0.77,-0.33）,P＜0.01].结论 根据现有资料表明,颅底脑膜瘤增长率小于非颅底的脑膜瘤.

Objective To evaluate the differences of the growth rate of skull base and non-skull base meningiomas.Methods The follow-up research literature about the growth of meningiomas was retrieved online.The eligible studies were analyzed by using Review Manager （version 5.3） software.Results （1） A total of 7 observational cohort studies met the requirements were enrolled,including 361 patients with meningioma without being treated.（2） The Meta analysis results showed that there were significant differences in the absolute growth rate （year）,relative growth rate （year）,doubling time （months） between the skull base meningiomas and non-skull base meningiomas （WMD =0.42,95% CI：0.20-0.64,P=0.000 2;WMD =1.05,95% CI：0.82-1.29,P〈0.01;WMD=-0.55,95% CI：-0.77--0.33,P 〈 0.01）.Conclusion The available information suggests that the growth rate of skull base meningiomas is less than that of the non-skull base meningiomas.