海洋天然产物立体构型研究进展

Current approaches to the configurational assignment of marine natural products

海洋天然产物是发现重要新型药物先导化合物的重要资源。海洋天然产物往往具有独特的结构骨架和复杂的立体构型,而化合物的立体构型往往与其生物活性息息相关。所以海洋天然产物的立体构型确定既是化合物结构研究的难点之一,也是天然产物非常重要的研究内容。本文简要综述了目前海洋天然产物立体构型确定的常用方法及其应用研究案例,旨在为天然药物化学研究提供一些参考和借鉴。

Marine natural products are a significant and important source for new small molecule drug leads. In most cases,marine natural products have unique structure skeletons and stereo complexity. Their absolute configurations and biologically activities are closely related, which highlights the importance of absolute configurational assignment. The stereo-configurational evaluation of marine natural products is one of the most difficulties in determining natural structure, and also very important contents of natural products research. In this review,we summarized a variety of cases with different structural types that often dictate some valuable approach to configurational assignment. Hopefully, the selected case studies could provide some inspiration to a readership with broad interests： natural products chemists and synthetic organic chemists.