海洋天然产物结构解析若干立体化学问题

Several stereogenic problems regarding structural elucidation of marine natural products

在天然产物结构解析中,常遇到立体化学问题(手性碳、轴不对称或面不对称)。确定其立体化学不仅是天然产物化学的重要内容之一,而且对阐明分子的靶向功能具有重要意义。现代波谱技术为天然产物构型确定提供了可靠的方法。本文结合作者的研究实例,综述应用现代波谱在若干海洋天然产物结构解析中的应用实例。

During the structural elucidation of natural products,one of the key steps is attributed to the solution of configuration including chiral carbons,axial and planar asymmetry. Stereogenic assignment is an essential work involved in natural product chemistry,while identification of stereogenic centers may be helpful to recognize the structure related to target function.Modern spectroscopic technology provided a reliable tool for the configurational assignment. In this paper,we intend to summarize part of our work regarding the application of extensive spectroscopic methods for the determination of the absolute configurations of marine-derived natural products.