地佐辛抑制全麻诱导期时芬太尼诱发咳嗽反射的效果

Effect of dezocine suppressing fentanyl-induced cough during general anesthesia induction

目的探讨地佐辛抑制全麻诱导期时芬太尼诱发咳嗽反射的效果。方法选择2013年3月—2014年3月本院收治的140例美国麻醉学家学会Ⅰ～Ⅱ级择期行全身麻醉患者,随机分为试验组和对照组各70例。试验组地佐辛0.1 mg/kg加生理盐水稀释成10 ml静脉注射,对照组以同样方法静脉注射等量生理盐水,2组10 min后于5 s内静脉注射芬太尼3 g/kg。在手术切口处进行浸润麻醉。注射芬太尼2 min后记录2组咳嗽发生率。结果试验组1例患者出现咳嗽,对照组53例出现咳嗽,2组间差异有统计学意义（P〈0.05）。结论地佐辛对抑制全麻诱导期时芬太尼诱发咳嗽反射效果良好。

Objective To evaluate the suppressive effect of intravenous dezocine on fentanyl-induced cough during the induction of general anesthesia.Methods 140 patients with induction of general anesthesia at March 2013 to March 2014,American Society of Anesthesiologists physical status I～Ⅱ,were randomly divided into two groups：experimental group（n=70）and control group（n=70）.Experimental group was given intravenous dezocine 0.1 mg/kg and 10 ml matching placebo at 10 min after induction of anesthesia.Control group was given 9%NaC1,10 ml placebo10 min after the induction of general anesthesia.The occurrence of cough was recorded 2 min after fentanyl bolus.Results 1 patient in the dezocine group had cough,and 53 patients in the control group had cough.The difference was statistically different between these two groups（P〈0.05）.Conclusion The results demonstrated that intravenous dezocine was more effective in suppressing fentanyl-induced cough in our patients.