9例胰岛细胞瘤诊治分析

Analysis of the treatment of 9 patients with islet cell tumor

目的对9例胰岛细胞瘤患者的诊治情况进行分析。方法回顾性分析1999年5月—2014年6月空军总医院收治的9例胰岛细胞瘤患者的临床表现、术前诊断、治疗方案及结局、病理特点和免疫组化并进行随访。结果功能性胰岛细胞瘤5例患者术前进行了血糖和胰岛素水平的测定,但仅2例检测了其他内分泌激素水平。全部患者术前均进行了影像学检查及手术治疗。良性胰岛细胞瘤或胰岛细胞增生6例术后随访至今未出现不适症状。恶性胰岛细胞瘤3例经手术或辅以术后联合治疗,2例生存至今未复发,1例死亡。结论胰岛细胞瘤的内分泌评估及多发性内分泌腺瘤病的筛查尚有待完善。

Object ive A nalysis the t reat ment of 9 patients with islet cell t u mor. Methods T hose 9 patients diagnosed as islet cell tumor, who were hospitalized in Air Force General Hospital from May 1999 to June 2014, were retrospectively analyzed in terms of clinical manifestation, pre-op diagnosis, treatment protocol and outcome, pathology feat u re, and im mu nohistochemist r y. Moreover, all these patients were follow-up st udied. Results A mong all these patients, 5 cases were tested with blood glucose and insulin pre-operation, yet only 2 patients were investigated with other hormone level. All patients accepted imaging examination before surgery. So far no discomfort symptom emerged among 6 cases of benign islet cell tumor or islet cell hyperplasia ones during post-op period. Among the malignant islet cell tumor patients who were operated on or assisted with combination therapy after surgery, 1 patient died, while 2 cases are alive till now without recurrence sign. Conclusion The endocrinologic evaluation of islet cell tumor and screen of multiple endocrine neoplasm is still expected to be consummated.