规模化养殖场猪粪源沙门氏菌的耐药性调查

Resistance of Salmonella Isolates from Swine Fecal in a Pig Farm to Antibiotics

为了解新疆乌鲁木齐周边某规模化猪场猪粪源沙门氏菌对临床常用抗菌药物的耐药情况,并将耐药数据用于指导该养殖场临床合理用药,采用琼脂稀释法对550份粪样中分离出的58株沙门氏菌进行最小抑菌浓度测定。结果显示:沙门氏菌对四环素(100.0%)、环丙沙星(96.6%)、恩诺沙星(94.8%)、阿莫西林/克拉维酸(91.4%)、卡那霉素(89.6%)、氟苯尼考(84.5%)和氨苄西林(75.9%)7种药物呈现高水平耐药;对阿米卡星(58.6%)、安普霉素(55.2%)、诺氟沙星(51.7%)和庆大霉素(50.0%)呈现中等水平耐药;仅对头孢噻呋(8.6%)敏感。该养殖场猪粪源沙门氏菌对临床常用抗菌药物耐药情况严重,临床应考虑联合用药、轮换用药。

In order to investigate the resistance of Salmonella isolated from a pig farm and guide reasonableuse of clinical antimicrobial drugs in Urumqi, Xinjiang, minimum inhibitory concentrations of 58 strains of Salmonella isolated from 550 fecal samples were determined by agar dilution method. The results showed thatthe resistance rate of Salmonella presented a high level to tetracycline（100.0%）, ciprofloxacin（96.6%）,enrofloxacin（94.8%）, amoxicillin/clavulanate（91.4%）, kanamycin（89.6%）, florfenicol（84.5%） and ampicillin（75.9%）; and presented a moderate level to amikacin（58.6%）, apramycin（55.2%）, norfloxacin（51.7%） andgentamicin（50.0%）; and was sensitive to ceftiofur（8.6%）. The resistance rate of Salmonella from pig fecal inthis farm to commonly used antibiotics was serious, indicating that alternative and combined use of antibioticsshould be adopted in the clinic.