补充维生素D和钙对超重多囊卵巢综合征患者血糖和血脂的影响

Evaluation of calcium plus vitamin D supplementation in overweight women with polycystic ovary syndrome

目的确定补充维生素D和钙对超重多囊卵巢综合征(PCOS)患者的糖代谢和脂代谢影响。方法对92例临床诊断为超重的PCOS患者进行随机双盲安慰剂对照的临床试验。参与者被随机分为4组:1联合给予钙剂+维生素D组(23例);2单纯给予钙剂组(23例);3单纯给予维生素D组(23例);4安慰剂组。药物干预8周,分别检测空腹血标本在治疗前和治疗后的糖代谢和血脂浓度。结果维生素D+钙组中血清钙浓度(P=0.01),维生素D含量(P=0.01)和极低密度脂蛋白胆固醇含量(P=0.002)明显高于其他组;血清胰岛素水平明显降低。总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇在4组间差异无统计学意义。结论代谢失调的肥胖PCOS患者补充维生素D和钙剂可降低患者的血脂、糖代谢异常的发生。

Objective To study the effects of vitamin D plus calcium supplementation on glucose metabolism and lipid concentrations among overweight women with polycystic ovary syndrome（PCOS）.Methods This randomized double-blind placebo-controlled clinical trial was conducted among 92 overweight women diagnosed with PCOS.Participants were randomly assigned into four groups to receive：1calcium＋vitamin D（n=23）;2calcium（n=23）;3vitamin D3（n=23）;4placebo control group（n=23）.After 8weeks,fasting blood samples were taken from control group and treatments groups to measure glucose metabolism index and lipid concentrations.Results Calcium＋vitamin D supplementation resulted in higher levels of serum calcium（P=0.01）,vitamin D（P=0.01）and serum VLDL-cholesterol levels（P=0.002）compared with other groups.Co-supplementation,compared with other groups,led to decreased serum insulin levels（P=0.03）.Furthermore,co-supplementation with calcium and vitamin D had no significant effects on total-,LDL-,HDL-cholesterol levels.Conclusion Calcium plus vitamin D supplementation among overweight women with PCOS had beneficial effects on glucose metabolism and lipid concentrations.