肥胖儿童血清Lep、PAEs及糖脂代谢的变化研究

Study on the change of serum Lep,PAEs,glucose and lipid metabolism of children with obesity

目的研究及观察肥胖儿童血清Lep、PAEs及糖脂代谢的变化情况。方法选取70例肥胖儿童设为观察组,另选同时期的70名体质量正常儿童为对照组,然后将2组的血清Lep、PAEs及糖脂代谢指标进行检测及比较,并比较观察组中轻度肥胖、中度肥胖及重度肥胖儿童及男童、女童的检测结果。结果观察组和对照组的血清Lep、PAEs及糖代谢、脂代谢指标之间存在显著差异,而观察组中轻度、中度及重度肥胖儿童间也存在显著差异,差异均有统计学意义(P<0.05),但男童与女童之间的检测结果差异则无统计学意义(P>0.05)。结论肥胖儿童血清Lep、PAEs及糖脂代谢情况明显异于体质量正常的儿童,且其表达水平受肥胖程度的影响较大。

Objective To study and observe the change situation of serum Lep,PAEs,glucose and lipid metabolism of children with obesity. Methods A total of 70 children with obesity were selected as observation group,70 children with normal weight at the same period were selected as control group,then the serum Lep,PAEs,glucose and lipid metabolism indexes of two groups were detected and compared,and the detection results of mild,moderate and severe obesity children were compared in the observation group. Results There were significant difference in the serum Lep,PAEs,glucose and lipid metabolism indexes of observation group and control group,and the detection indexes of mild,moderate and severe obesity of children were statistically significant（ P 0. 05）,but the detection results in the observation group had no obvious significant differences（ P 0. 05）. Conclusion The situation of serum Lep,PAEs,glucose and lipid metabolism of children with obesity are obviously different from the children with normal weight,and the influence of obesity degree for their expression levels is great.