神经型一氧化氮合酶竞争性底物抑制剂的研究进展被引量：3

Progress in research of competitive inhibitors for neuronal nitric oxide synthase

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摘要一氧化氮(NO)是人体内一种关键的生物信号分子,它在神经传导、血压调节、免疫激活中扮演重要角色。神经型一氧化氮合酶(n NOS)产生的NO在正常生理浓度下有神经保护作用,但在病理状态下,n NOS过量产生的NO与多种神经退行性疾病、神经痛有密切的联系。选择性抑制n NOS有望治疗多种神经系统疾病。本文将介绍一些n NOS选择型抑制剂,重点介绍2-氨基吡啶类和噻吩-2-甲脒类n NOS抑制剂。 Nitric oxide（ NO） plays a critical role in human body,and affects neuronal signaling,blood pressure and immune activation. NO generated by neuronal nitric oxide synthase（ n NOS） is neuroproctective at normal physiological concentrations. However,in pathological conditions,NO associates with many neurodegenerative disorders as well as neuropathic pain. n NOS-selective inhibition is a promising therapeutic method for these disorders. This article will introduce some competitive n NOS-selective inhibitors,especially the compounds derived from 2-aminopyridines and thiophene-2-carboximidamides.

作者丁屹蔡鋆鑫厉廷有

机构地区南京医科大学药学院

出处《中国新药杂志》 CAS CSCD 北大核心 2015年第24期2814-2825,共12页 Chinese Journal of New Drugs

基金江苏省心血管病转化医学协同创新中心

关键词一氧化氮神经型一氧化氮合酶神经退行性疾病一氧化氮合酶选择型抑制剂 nitric oxide nitric oxide synthase neurodegenerative disorders nitric oxide synthase-selective inhibitors

分类号 R971.3 [医药卫生—药品]

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