滨州地区妇女宫颈人乳头瘤病毒感染现状的调查

Investigation of Human Papillomavirus Infectionin Cervix of Women in Binzhou

目的了解山东省滨州地区成年妇女子宫颈人乳头瘤病毒（humanpapillomavirus，HPV）感染情况与基因型的分布，为本地区HPV分子流行病学研究与子宫颈癌的预防提供一定的理论基础。方法采集721例妇科门诊成年妇女的宫颈脱落细胞为标本，导流杂交PCR法检测HPV基因型并分析不同年龄组、不同居住地患者问感染率的差异。结果滨州地区妇科门诊患者子宫颈HPV总的感染率为26．76％，高危型感染率为18．44％，低危型感染率8．32％，高危型中共检出12中亚型，感染率前3名分别为16型（3．19％）、58型（2．35％）66型（2．08％）；低危型中感染率最高为43型（2．77％）。20～30岁与50-60岁年龄段总感染率高于其他年龄段，分别为47．36％、32．23％；城镇居住地者与农村居住地者HPV感染率分别为25．74％、27．97％，两者间无显著性差异。结论滨州地区妇女宫颈人乳头瘤病毒具有本区域的流行分布特征，可为该地区HPV感染的防治提供一定的理论基础。

Objective To investigate the prevalence of cervical human papillomaverus infection and subtype distribution in woman in Bin Zhou, and to provide some reference foundation for prevention from cervical cancer. Methods The cervical exfoliated cells from 721 women in out-patient in Bin Cheng hospital were collected. The flow through hybridizotion technique was used to detect 23 kinds of HPV genotypes. The infection rate of HPV in different age stage was analyzed. Results The total infection rate of HPV in Binzhou was 26.76% and the HR- HPV rate was 18.44%. The top three infection prevalence rates of HPV genotypes were 16 genotype （3. 19% ）, 58 genotype （2.53%） and 66 genotype （2.08%）. The LR-HPV rate was 8.32% and the highest rate genotype was 43 （2.77%）. The highest prevalence rate was found among the age of 20 to 30 and 50 to 60 with prevalence rate was 47.36% and 32.23% respectively. The prevalence rate in urban woman and rural woman were 25.74% and 27.97% respectively. Conclusion The infection prevalence of HPV in Binzhou of Shandong province is with area characteristic and may provide some basic information to prevent the HPV infections.