C肽在糖尿病肾病中的临床意义

Clinical Value of C-peptide in Patients with Diabetic Nephropathy

目的了解糖尿病肾病患者C肽分泌特点及临床意义。方法 1选取行胰岛功能检查的住院患者86例,依出院诊断结果,将其分为两组:仅糖尿病组(DM)、糖尿病肾病组(DN),并将DN分为5期(I^V期);2比较两组相关因素有无差异并分析DN患者C肽分泌特点;3分析DN分期特点及各期C肽分泌特点。结果 1DN组和仅DM组相比,性别、年龄、血压、血脂、空腹血糖均无统计学差异(P>0.05);2两组C肽分泌高峰均延迟,DN组分泌高峰在餐后3h,而仅DM组在餐后2小时;3DN以III、IV期多见,占DN的91.9%,相比而言,I、II期较少,仅占1.6%;任一期的C肽分泌高峰均在餐后3h;对比各期的C肽值,差异无统计学意义(P>0.05)。结论 DN患者的相关因素与仅DM患者相似,当发现DN时,患者肾脏及胰岛功能往往受损较重,但C肽与DN不同分期间无明显相关性。

Objective To investigate the secretion characteristics and clinical significance of C-peptide in patients with diabetic nephropathy. Methods 86 cases of patients were divided into diabetes（DM） and diabetic nephropathy （DN） group based on their pancreatic function check-up results. The serum C-peptides levels and secretion characteristic in DN patients were detected and analyzed. Results The gender, age, blood pressure, blood lipid and fasting blood glucose had no statistical significance between DN group and DM group （P 〉 0.05 ）. The C-peptide secretion peak was delayed in both two group patients, and the DN group was in 3h after a meal, while DM group was in 2h after a meal. The stages of phase III and IV in DN patients were common and accounted for 91.9%, while the stage of phase I and II was lesser and only accounted for 1.6%. The C- peptide secretion peak in all stages of DN patients was 3h after the meal. There was no statistical significance in C-peptide values among different DN stages（P 〉 0. 05）. Conclusion The patients with diabetic nephropathy often have severe damage of kidney and pancreatic function, but the C peptide levels might be irrelevant to different stages of DN.