曲美他嗪对伴有高血压的冠心病患者心脏舒张功能的影响

Effect of trimetazidine on left ventricular diastolic function in the patients with coronary heart disease andessential hypertension

目的探讨曲美他嗪对伴有高血压的冠心病患者心脏舒张功能的影响。方法 "IL-33和e NOS基因标签SNPs与冠心病发生的关联研究"中伴高血压、左心收缩功能正常而左室舒张功能异常、经冠脉造影确诊的冠心病患者143例,73例患者在冠心病二级预防治疗、血压控制达标基础上加用了曲美他嗪片治疗作为治疗组,70例患者给予冠心病二级预防、控制血压达标作为对照组,观察12周,采用多普勒超声心动图检测冠心病患者治疗前后左室收缩功能指标射血分数(LVEF),左室舒张功能指标E波峰值速度(E)、A波峰值速度(A)、E峰与A峰速度比值(E/A),采用SPSS 13.0统计软件对两组患者检测指标进行统计学分析比较,对两组患者治疗前后上述指标变化进行t检验。结果两组治疗后左室收缩功能指标及舒张功能指标与治疗前相比较均有改善,差异有统计学意义(P<0.05);治疗后治疗组左室收缩功能指标及舒张功能指标较对照组改善显著,差异有统计学意义(P<0.05)。结论曲美他嗪对伴有高血压的冠心病患者心脏舒张功能有改善作用。

Objectives To evaluate the effect of trimetazidineon left ventricular diastolic function in the patients with coronary heart disease and essential hypertension by using tissue doppler imaging（ TDI） technology. Methods 143 cases of patients with coronary heart disease andessential hypertensionaccompanied by ventricular diastolicdysfunction were randomly divided into two groups,the treatment group（ n = 73） and control group（ n = 70）. Control group with Two grade prevention and treatment of coronary heart disease and antihypertensive therapy,treatment group on the basis of control group treatment combined trimetazidine 20 mg,3 times per day for 12 weeks. Results After treatment,the left ventricular diastolic function indicator（ E / A ratio） and left ventricular systolic function indicator（ LVEF） of two groups significantly increased（ P〈0. 05）,the left ventricular diastolic function indicator（ E /A ratio） and left ventricular systolic function indicator（ LVEF） of treatment group improved better compared with the control group（ P〈0. 05）. Conclusions Two grade prevention and treatment of coronary heart disease andantihypertensive therapycombined trimetazidinecan improve left ventricular diastolic function and left ventricular systolic function and left ventricular systolic function in patients with coronary heart diseaseandessential hypertension.