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维生素D受体基因多态性与冠心病的相关性 被引量：5

Correlation between vitamin D receptor gene polymorphism and coronary heart disease
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摘要 近年来国内外研究均证实维生素D能够抑制炎症反应程度,从而具有延缓冠状动脉粥样硬化的作用,而维生素D的作用通过维生素D受体来实现,现已知维生素D受体基因存在变异,而这些变异可能影响维生素D的作用。本文拟就维生素D及其受体基因变异与动脉硬化相关心血管疾病的关系进行综述。 In recent years,national and international studies haveconfirmed that vitamin D can inhibit inflammatory reaction,thereforehas anti-atherosclerosis effect. Theeffect of vitamin D is through vitamin D receptors. It is known that thepresenceof thevitamin D receptor genemutation may affect theroleof vitamin D. This paper reviews thevitamin D receptor genevariant and its relation to atherosclerosis-related cardiovascular disease.
作者 潘楠楠 孟佳 迟啸威 姜礼红
机构地区 哈尔滨医科大学附属第二医院
出处 《中国骨质疏松杂志》 CAS CSCD 北大核心 2015年第12期1526-1528,共3页 Chinese Journal of Osteoporosis
关键词 维生素D受体 基因多态性 冠心病 Vitamin D receptor Gene polymorphisms Coronary artery disease
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献10

  • 1Michael F, Holick MD. Vitamin D deficiency. N EnglJ Med, 2007,357 :266-281.
  • 2Giovannucci E, Liu Y, Hollis BW ,et al. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med,2008,168(11) :1174-1180.
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  • 6Ferrarezi DA, Bellili-Muftoz N, Dubois-Laforgue D, et al. Allelic variations of the vitamin D receptor (VDR) gene are associated with increased risk of coronary artery disease in type 2 diabetics: the DIABHYCAR prospective study. Diabetes Metab, 2013, 39 (3) :263-270.
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同被引文献57

  • 1宁云芳,王晓林,吕艳丽,荣书玲.维生素D3对大鼠心肌缺血再灌注模型心肌功能的保护作用机制[J].中华生物医学工程杂志,2018,24(6):381-385. 被引量：7
  • 2Rosen CJ. Vitamin D Insufficiency[J]. N Engl J Med, 2011, 364(1): 248: 254.
  • 3Giovannueci E, Liu Y, Hollis BW, et al. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study[J]. Arch Intern Med, 2008, 168(11): 1174-1180.
  • 4Motiwala SR, Wang TJ. Vitamin D and cardiovascular risk[J]. Curr Hypertens Rep, 2012, 14(3): 209-218.
  • 5Mertens PR, Muller R. Vitamin D and candiovascular risk[J]. Int Urol Nephrol, 2010, 42: 165-171.
  • 6Kienreich K, Tomaschitz A, Verheyen N, et al. Vitamin D and cardiovascular disease[J], Nutrients, 2013, 5(8): 3005 -3021.
  • 7Heidari B, Nargesi AA, Hafezi-Nejad N, et al. Assessment of serum 25-hydroxy vitamin D improves coronary heart disease risk stratification in patients with type 2 diabetes[J]. American Heart Journal, 2015, 170(3): 573-579.
  • 8Jha P, Dolan LM, Khoury PR, et al. Low serum vitamin D levels are associated with increased arterial stiffness in youth with type 2 diabetes[J]. Diabetes Care, 2015, 38(8): 1551-1557.
  • 9Brondum Jacobsen P, Nordestgaard BG, Schnohr P, et al. 25 Hydroxyvitamin D and symptomatic ischemic stroke: all original study andmeta-analysis[J]. Ann Neurol, 2013, 73(1): 38-47.
  • 10Sokol SI, Srinivas V, Crandall J P, et al. The effects of vitamin D repletion on endothelial function and inflammation in patients with coronary artery disease[J]. Vasc Med, 2012, 17(6): 394-404.

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中国骨质疏松杂志
2015年 第12期

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