N端脑钠肽前体联合血清同型半胱氨酸联合检测在慢性心力衰竭中的应用

The Application of N-terminal Brain Natriuretic Peptide and Serum Homocysteine Combined Detection in Chronic Heart Failure

目的:探讨N端脑钠肽前体及血清同型半胱氨酸联合检测在慢性心力衰竭(CHF)诊断中的应用。方法:选择2012年6月-2014年10月笔者所在医院收治的CHF患者70例为观察组,上述患者再根据心功能分级进行等级分组,同时选择同期体检健康人群70例为对照组,检测及比较两组人员及不同心功能分级患者的NT-pro BNP以及Hcy水平。结果:与对照组NT-pro BNP(183.7±5.2)ng/L及Hcy水平(9.8±1.4)μmol/L比较,观察组NT-pro BNP(3141.1±198.3)ng/L及Hcy水平(21.5±3.7)μmol/L明显高,差异有统计学意义(P<0.05);随着NYHA分级增加,NT-pro BNP及Hcy水平逐渐升高,差异有统计学意义(P<0.05)。结论:血清NT-pro BNP及Hcy水平可作为慢性心力衰竭的诊断参考,且上述指标含量与其心功能分级相关,可作为疾病程度的判断指标之一。

Objective： To investigate the application of N-terminal brain natriuretic peptide and serum homocysteine combined detection in patients with chronic heart failufe（CHF）.Method： 70 cases of CHF which treated in our hospital from June 2012 to October 2014 were selected as the observation group, these patients were grouped according to NYHA grade, while the saree period 70 cases of physical healthy people were selected as the control group, NT-pmBNP and HCY levels in both groups and different NYHA classification patiens were tested and compared.Result： The observation group NT-proBNP was （3141.1 ± 198.3）ng/L and Hcy levels was （21.5 ±3.7）μmol/L, compared with the control group of NT-proBNP was （183.7 ± 5.2）ng/L and Hcy levels （9.8 ± 1.4）μ mol/L, the differences were statistically significant（P〈0.05）, with NYHA class increase, NT-proBNP and Hcy levels gradually increased, the differences were statistically significant（P〈0.05）.Conclusion： Serum levels of NT-proBNP and Hcy can see as chronic heart failure diagnosis reference, and the indexs content relevant to their functional class, can be used as indicators to determine the extent of the disease.