阿魏酸钠对缺血性心力衰竭患者6min步行距离及血浆脑钠肽的影响

THE INFLUENCE OF FERULIC ACID SODIUM ON 6 MINUTES WALKING DISTANCE AND PLASMA BRAIN NATRIURETIC PEPTIDE LEVELS IN PATIENTS WITH ISCHEMIC HEART FAILURe

目的探讨阿魏酸钠对缺血性心力衰竭患者6min步行距离及血浆脑钠肽(BNP)的影响水平及机制。方法选择缺血性心力衰竭患者165例,随机分为二组,观察组82例,对照组83例,二组患者均常规给予强心、利尿、扩血管、β-受体阻滞剂等治疗。观察组在常规治疗基础上加用阿魏酸钠注射液300mg静脉滴注,1次/d,疗程14d。结果二组患者治疗后6min步行距离均有增加,观察组较对照组增加的距离更加明显。二组患者治疗后血浆脑钠肽水平均有下降,观察组较对照组下降的更为明显。结论阿魏酸钠治疗缺血性心力衰竭患者,6min步行距离明显增加,同时降低患者血浆脑钠肽水平,从而减少心脏事件。

Objective To study the affect of Ferulic acid sodium in patients with ischemic heart failure on 6 minutes walking distance and plasma brain natriuretic peptide（BNP）levels and its mechanism.Methods Totally165 patients with ischemic heart failure were randomly divided into two groups,the treatment group of 82 subjects,the control group of 83 cases.Two groups of patients were routinely offer blood vessels,strong heart,diuresis,enlarge the treatment such as beta blockers.The treatment group on the basis of conventional treatment combined with ferulic acid sodium injection300 mg intravenous drip,once a day,the course of 14 days.ResultsAfter treatment,6 minutes walking distance in two groups of patients were increased,and increased distance is more obvious in the treatment group than the control group.Plasma brain natriuretic peptide levels after treatment in both groups were falling,and it fell more obviously in the treatment group than the control group.ConclusionSodium ferulic acid treatment for ischemic heart failure patients,6 minutes walking distance is increased,at the same time reduces the patients plasma brain natriuretic peptide levels,thus reduce heart events.