宫颈癌盆腔淋巴结转移的危险因素分析

Risk Factors of cervical cancer with pelvic lylmph node metastasis

目的探讨宫颈癌盆腔淋巴结转移的相关危险因素。方法对502例Ⅰb-Ⅱb期宫颈癌根治术后患者的临床与病理资料进行回顾性分析。结果盆腔琳巴结转移率为21.91%(110/502),单因素分析显示肿瘤大小、临床分期、肌层浸润深度、宫旁切缘、病理分级、脉管瘤栓与盆腔淋巴结转移有关(P<0.05)。Logistic回归多因素分析显示肌层浸润深度、临床分期、病理分级、脉管瘤栓为盆腔淋巴结转移的独立危险因素(P<0.05)。结论临床分期晚,病理分级差,肌层浸润>1/2,脉管瘤栓阳性为宫颈癌淋巴结转移的高危因素。

Objective To investigate the risk factors of cervical cancer with pelvic lylmph node metastasis. Methods The clinical and pathological data of 502 patients with cervical carcinoma of stage Ⅰ b -Ⅱ b after radical hysterectomy and pelvic lymphadenectomy were ret- rospectively analysed. Results The rate of lymphnode metastasis was 21.91%. In univariate analysis, pelvic lymph node metastasis was asso- ciated with tumor size, clinical stage, myometrial invasion, parametrial extension, pathological grade and lymph vascular space involvement （ P 〈 0. 05 ）. While in Logistic multivariate analysis, the independent factors included pathological grade, clinical stage, pathological grade and lymph vascular space involvement（ P 〈 0. 05 ）. Conclusion The late stage, worse in pathological grade, myometrial invasion 〉 1/2, positive lymph vascular space involvement are the high risk factors of lymph node metastasis.