老年肾癌服用苹果酸舒尼替尼的护理体会

Nursing care of aged renal cell carcinoma during treatment with sunitinib malate

目的探讨老年肾癌患者服用苹果酸舒尼替尼过程中不良反应与护理特点,为临床安全合理用药提供参考。方法回顾分析应用苹果酸舒尼替尼治疗的36例老年晚期肾癌患者的临床资料,了解不良反应特点,对老年肾癌患者进行干预护理。结果本组不良反应发生率为手足综合征14(38.9%)、高血压19(52.8%)、腹泻21例(58.3%)、乏力22(61.1%)、口腔炎9(25%)、恶心呕吐7(19.5%)、甲状腺功能异常7(19.4%)、血液学毒性14(38.9%)等,其中手足综合征,高血压,腹泻和乏力发生率稍高于文献。护理干预后症状可减轻。结论老年患者服用苹果酸舒尼替尼安全有效,积极护理干预有助于提高老年患者耐受性。

Objective To investigate adverse reactions and nursing characteristics of aged patients with renal cell carcinoma during the treatment with sunitinib malate, and to provide the verificatioh of clinical safety and reasonable application of sunitinib. Methods Thirty - six aged patients with renal cell carcinoma treated with sunitinib malate were analyzed retrospectively. Patient characteristics and adverse reactions were analyzed and the nursing care given were evaluated. Results Common treatment - related adverse events were hand - foot syndrome （38.9%）, hypertension（52. 8% ）, diarrhea（ 58.3% ）, fatigue （61.1% ）, stomatitis （25）, nausea and vomiting（ 19. 5 ）, thyroid dysfunction （ 19.4）, and neutropenia and thrombocytopenia（38. 9% ）. The adverse events incidence of hand - foot syndrome, hypertension, diarrhea and fatigue were slightly higher than that of published literature. Signs and symptoms of adverse reactions were alleviated when reasonable nursing care was given to the patients. Conclusion Sunitinib malate was efficacious and did not cause increased toxicity in aged patients with renal cell carcinoma, and active nursing intervention can improve tolerance of such patients.