血清STIM1及Adropin含量对PCI术后心血管事件和再狭窄的预测价值研究

Predictive value of serum STIM1 and Adropin contents in cardiovascular events and restenosis after PCI operation

目的:研究血清基质交感分子1(STIM1)及Adropin含量对经皮冠状动脉介入治疗(PCI)术后心血管事件和再狭窄的预测价值。方法:选择在广东省高州市人民医院接受PCI的单支冠状动脉病变病患者进行研究,筛选PCI术后6个月时支架内狭窄超过50%的45例纳入ISR组、支架内狭窄未超过50%的85例纳入NISR组,测定两组血清STIM1、Adropin、NO含量以及外周血中内皮祖细胞含量、内皮微粒数目。结果:ISR组血清中STIM1的含量高于NISR组且STIM1含量与管腔狭窄程度呈正相关,ISR组血清中Adropin的含量低于NISR组且Adropin含量与管腔狭窄程度呈负相关;ISR组外周血中内皮祖细胞含量、血清中NO含量少于NISR组,外周血中内皮微粒数目多于NISR组;血清STIM1含量与外周血中内皮微粒数目呈正相关、与外周血中内皮祖细胞含量呈负相关,血清Adropin含量与外周血中内皮微颗粒数目呈负相关、与外周血清中NO含量呈正相关。结论:血清STIM1含量升高、Adropin含量降低与PCI术后心血管事件和再狭窄的发生相关,两类分子主要影响内皮细胞功能和内皮祖细胞归巢。

Objective： To study the predictive value of serum STIM1 and Adropin contents in cardiovascular events and restenosis after PCI operation. Methods： Single coronary artery lesion patients receiving percutaneous coronary intervention in our hospital from May 2014 to January 2015 were selected. A total of 45 cases with more than 50% of in-stent restenosis area 6 months after PCI operation were enrolled in ISR group, 85 cases of patients with less than 50% of in-stent restenosis area were enrolled in NISR group, and then serum STIM1, Adropin and NO contents as well as endothelial progenitor cell content and endothelial micropartiele number in peripheral blood of two groups were detected. Results： Serum STIM1 content of ISR group was significantly higher than that of NISR group and STIM1 content was positively correlated with lumen stenosis degree. Serum Adropin content of ISR group was significantly lower than that of NISR group and Adropin content was negatively correlated with lumen stenosis degree. Endothelial progenitor cell content in peripheral blood and serum NO content of ISR group were lower than those of NISR group, and endothelial microparticle number in peripheral blood was higher than that of NISR group. Serum STIM1 content was positively correlated with endothelial microparticle number in peripheral blood and negatively correlated with endothelial progenitor cell content in peripheral blood. Serum Adropin content was negatively correlated with endothelial microparticle number in peripheral blood and positively correlated with serum NO content. Oonclusiom Serum STIM1 content increase and Adropin content decrease are related to the occurrence of cardiovascular events and restenosis after PCI operation, which mainly affect endothelial cell function and endothelial progenitor cell homing.