血清Hcy与C反应蛋白对心血管类疾病诊治及预后判断的价值

Application of serum Hcy and C reactive protein in diagnosis,treatment and prognosis of cardiovascular diseases

目的：研究探讨血清Hcy与C反应蛋白检测在心血管类疾病中的诊治及预后应用价值.方法：选择2012年6月～2015年6月在安康市中心医院接受诊治的心血管类疾病患者126例实施研究,根据疾病种类进行分组,其中冠心病组44例,心肌梗死组42例,心绞痛组40例,另选同期在我院的40例H型高血压患者作为H型高血压组,以及进行健康体检的40例志愿者作为对照组,对比各组患者的血清Hcy及CRP水平及异常检出率情况,分析血清Hcy及CRP对心血管类疾病的诊断价值.结果：冠心病组和心肌梗死组,以及心绞痛组患者的血清Hcy及CRP水平均分别显著高于对照组及H型高血压组（均P＜0.05）.但冠心病组、心肌梗死组以及心绞痛组患者组间比较血清Hcy及CRP水平,差异无统计学意义（P＞0.05）.冠心病组和心肌梗死组,以及心绞痛组患者的血清Hcy及CRP异常检出率均分别显著高于对照组及H型高血压组（P＜0.05）.但冠心病组和心肌梗死组,以及心绞痛组患者组间比较血清Hcy及CRP异常检出率,差异无统计学意义（P＞0.05）.联合血清Hcy及CRP对冠心病、心肌梗死以及心绞痛疾病的诊断准确率最高,分别达到97.73％、94.62％及97.50％.联合血清Hcy及CRP检测对心血管类疾病并发症及预后的预测时间显著少于单用血清Hcy及CRP,差异有统计学意义（P＜0.05）.结论：联合检测血清Hcy以及CRP,对心血管类疾病患者具有较好的预测价值,效果明显,值得在临床上广泛应用.

Objective： To investigate application of serum Hcy and C reactive protein in diagnosis, treatment and prognosis of cardiovascular diseases. Methods.. From June 2012 to June 2015, 126 cases of cardiovascular disease were selected. There were 44 cases in coronary heart disease group, 42 cases in myocardial infarction group, and 40 cases in angina pectoris group. Another 40 patients with H type hypertension were selected as the type H hypertension group and 40 cases of healthy volunteers as control group. Serum Hcy and hs CRP levels and abnormal detection rate of diagnostic value of serum Hcy and hs CRP of cardiovascular diseases were compared. Results; The levels of serum Hcy and CRP in patients with coronary heart disease group and myocardial infarction group were significantly higher than those in control group and H type hypertension group （P〈0.05）. However, there was no significant difference in the levels of serum Hey and CRP between the patients with coro- nary heart disease, myocardial infarction and angina pectoris （P〉0.05）. The positive rate of serum Hcy and CRP were significantly higher than those in the control group and H type hypertension group （P〈0.05）. However, there was no significant difference in the detection rate of Hcy and CRP between the patients with coronary heart disease （CHD） and myocardial infarction group, and the patients with angina pectoris （P〉0.05）. Combined serum Hcy and CRP in the diagnosis of coronary heart disease, myocardial infarction and angina pectoris were the highest, reaching 97.73%, 94.62% and 97.50% respectively. The prognosis time of combined with Hcy and CRP test for cardiovascular disease complications and prognosis was significantly shorter than that of Hcy and CRP （P〈0.05）. Conclusion： Combined detection of serum Hcy and CRP has predictive value for patients with cardiovascular disease. The effect is obvious, and it is worthy of wide application in clinic.