天晴甘平与复方甘草酸单胺对白血病化疗患者肝脏的保护作用

Effect of glycyrrhizic acid diamine capsules and compound ammonium glycyrrhetate on liver protection in patients with leukemia undergoing chemotherapy

目的探讨天晴甘平(甘草酸二铵肠溶胶囊)与复方甘草酸单胺对白血病化疗患者肝脏的保护作用。方法选取2012年1月至2014年12月我科收治的52例白血病化疗后出现药物性肝功能损害患者,随机将其分为观察组与对照组各26例,观察组采用天晴甘平治疗,对照组采用复方甘草酸单胺注射液治疗,两组持续治疗14 d。观察两组患者的临床疗效、症状改善及药物毒副作用。结果观察组的治疗总有效率为88.4%,明显高于对照组的65.4%,两组比较差异具有统计学意义(P<0.05);治疗7 d、14 d后,观察组患者的谷丙转氨酶(ALT)、谷草转氨酶(AST)值改善均明显优于同期对照组,差异均有统计学意义(P<0.05);观察组治疗后周身无力、消化系统表现以及肝区隐痛等临床症状恢复用时均比对照组有明显缩短,差异均有统计学意义(P<0.05);观察组未出现明显不良反应,而对照组出现4例,两组比较差异具有统计学意义(P<0.05)。结论天晴甘平治疗白血病化疗后药物性肝功能损害的临床疗效优于复方甘草酸单胺注射液,且其具有快速改善症状、药物副作用低等优点,值得临床推广应用。

Objective To explore the liver protective effect of Tian Qing Gan Ping（glycyrrhizic acid diamine capsules） and compound ammonium glycyrrhetatein in patients with leukemia undergoing chemotherapy.Methods A total of 52 patients of leukemia with drug-induced liver injury after chemotherapy from January 2012 to December 2012 were randomly divided into observation group（n=26） and control group（n=26）. The observation group was treated with glycyrrhizic acid diamine capsules, and the control group was treated with compound ammonium glycyrrhetate injection. The two groups were both treated for 14 d. The clinical curative effect, symptom improvement, drug side effects were observed. Results The total effective rate was 88.4% in the observation group and65.4% in the control group, with statistically significant difference（P〈0.05）. After 7 d, 14 d of treatment, the improvements in alanine aminotransferase（ALT） and aspertate aminotransferase（AST） value of the observation group were significantly better than those in the control group at the same period（P〈0.05）. In the observation group, the recovery times of body-weakness, digestive system and clinical symptom such as liver area ache after treatment were significantly shorter, compared with those of the control group（P〈0.05）. The observation group did not appear obvious adverse reactions, while the control group had 4 cases of adverse reactions, with statistically significant difference（P〈0.05）.Conclusion Glycyrrhizic acid diamine has better clinical curative effect in the treatment of drug-induced liver injury after chemotherapy in patients of leukemia than compound ammonium glycyrrhetatein, which can improve symptoms fast and has low drug side effects. It is worthy of clinical popularization and application.