参苓白术散加减辅助治疗2型糖尿病伴肥胖症80例临床观察

Clinical effect of additive Shenlingbaizhusan decoction in the treatment of 80 patients with type 2 diabetes mellitus complicated with obesity

目的观察参苓白术散加减辅助治疗2型糖尿病伴肥胖症的临床疗效。方法选取符合纳入标准的2型糖尿病伴肥胖症患者80例,随机分为观察组和对照组各40例,两组均给予胰岛素治疗(三短一长),观察组在胰岛素治疗基础上加服参苓白术散加减方,疗程12周,观察两组治疗前后空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb A1c)、体重指数(BMI)、腰臀比(WHR),评判疗效。结果观察组患者治疗后的FPG、2 h PG、Hb A1c、BMI、WHR明显好于对照组,差异均有统计学意义(P<0.05),且服药期间无明显不良反应,依从性好。结论参苓白术散加减方可有助降低血糖、减轻体重,对于2型糖尿病伴肥胖症患者,具有较好疗效。

Objective To observe the effect of additive shenlingbaizhusan decoction in the treatment of type2 diabetes mellitus（T2DM） complicated with obesity. Methods Eighty patients of T2 DM complicated with obesity were selected and randomly divided into two groups： the treatment group（n=40） and the control group（n=40）. The two groups were both treated with insulin therapy, and the treatment group was treated additionally with shenlingbaizhusan therapy. The course of treatment was 12 weeks. The level of fasting plasma glucose（FPG）, 2-hour plasma glucose（2 h PG）, glycosylated hemoglobin A1c（Hb A1c）, body mass index（BMI） and waist-hip ratio（WHR） of the two groups were observed, and the clinical efficacy was evaluated. Results In the treatment group, the FPG, 2 h PG,Hb A1 c, BMI and WHR were significantly better than those in the control group, with no obvious adverse reaction and good comp1 iance. Conclusion Shenlingbaizhusan can down-regulate the level of blood glucose and contribute to weight loss, which has great clinical effect for patients of T2 DM complicated with obesity.