婴幼儿喘息性疾病与食物不耐受相关性研究

Correlation analysis between food intolerance and asthmatic disease in infants

目的分析婴幼儿喘息性疾病与食物不耐受之间的相关性,以期为婴幼儿喘息性疾病的防治提供参考。方法回顾性收集我院儿科门急诊及病房2010年10月至2014年12月就诊的120例喘息婴幼儿的临床资料(患病组),以同一时期在我院进行儿保查体的80例婴幼儿的临床资料作为对照(正常组),比较两组婴幼儿食物不耐受的情况及不耐受食物种类的分布情况,同时进行以食物不耐受为因变量的Logistic回归分析。结果 1正常组和患病组食物不耐受种类前三位均为牛奶、蛋清/蛋黄、鳕鱼,但患病组不耐受的比例显著高于正常组,差异均具有显著统计学意义(P<0.05);2患病组中,一种食物不耐受、两种食物不耐受和三种以上食物不耐受的比例均显著高于正常组,差异均具有显著统计学意义(P<0.01);3以食物不耐受为因变量的Logistic回归分析结果显示,患病组患儿的性别、年龄、体重三个变量与食物不耐受无统计学相关性(P>0.05),而白细胞增多、嗜酸性粒细胞增多、C-反应蛋白增加与食物不耐受显著相关(P<0.05)。结论食物不耐受与婴幼儿喘息性疾病的发生密切相关,其不仅能为喘息性疾病婴幼儿的诊断和治疗提供参考,而且能指导喘息性疾病婴幼儿的饮食。

Objective To investigate and analyze the correlation between food intolerance and asthmatic disease in infants, thereby providing reference for prevention and cure of asthmatic disease. Methods The clinical data of 120 infants with asthmatic disease in our hospital from October 2010 to December 2014（illness group） were collected. Eighty healthy infants for health check in the same period were enrolled as the control group. The rate of food intolerance in infants and the distributions of food intolerance type in the two groups were compared. Simultaneously,logistic regression analysis was carried out with food intolerance as the dependent variable. Results 1 Food intolerance to milk, egg white/yolk and codfish were high in the two groups, but the intolerance rate was significantly higher in the illness group than the control group（P〈0.05）. 2 The proportions for intolerance to one type of food, two types of food, three or more types of food in the illness group were all significantly higher than those in the control group（P〈0.01）. 3 Logistic regression analysis showed that gender, age and body weight in the illness group had no significant correlation with food intolerance（P〉0.05）, while increased leukocytosis, eosinophils and C-reactive protein showed significant correlation with food intolerance（P〈0.05）. Conclusion Food intolerance is closely related to the occurrence of asthmatic disease in infants. It not only plays an important role in the diagnosis and treatment of asthmatic disease, but also provides more comprehensive guidance of diet for infants with asthmatic disease.