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IL-27在肿瘤免疫治疗中的潜在价值 被引量：6

IL-27 as a potential immunotherapeutic for cancer
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摘要 白介素27是具有独特免疫调节功能的细胞因子,可促进抗肿瘤Th1/Tc1免疫应答,去除Treg细胞亚群,同时它也能去除Th17细胞亚群和上调IL-10以抑制自身免疫发展。本文综述IL-27对T细胞免疫调节的特性,分析其在肿瘤免疫治疗中的潜在价值。 Interleukin 27 is a unique cytokine that increase Th1/Tc1 response and eliminate Treg cell,contributing to antitumor T cell response. On the other hand, IL-27 can also eliminate Th17 and increase IL-10 product of T cell, which potentially limit autoimmune disease. We review and discuss the role of IL-27 in antitumorT cell response in this paper, for further developing IL-27 base antitumor strategy.
作者 刘智豪 朱小彤 李明松 周杰
机构地区 南方医科大学南方医院肝胆外科 南方医科大学南方医院消化内科
出处 《免疫学杂志》 CAS CSCD 北大核心 2016年第1期89-92,共4页 Immunological Journal
关键词 白介素27 T细胞 肿瘤 自身免疫炎症 IL-27 T cell Neoplasms Autoimmune disease
分类号 R730.51 [医药卫生—肿瘤]
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参考文献30

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  • 2Pflanz S, Hibbert L, Mattson J, et al. WSX -I and glycoprotein 130 constitute a signal-transducing receptor for IL-27[J]. J Immunol, 2004,172(4): 2225-223l.
  • 3Takeda A, Hamano S, Yamanaka A, et al. Cutting edge: role of IL-27IWSX-I signaling for induction of T-bet through activation of STATl during initial Thl commitment[J]. J Immunol, 2003, 170(10): 4886-4890.
  • 4Yoshimura T, Takeda A, Hamano S, et al. Two-sided roles of IL-27: induction of Th l differentiation on naive CD4' T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4' T cells partially through STAT3-dependent mechanism[J]. J Immunol, 2006,177(8): 5377-5385.
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同被引文献29

引证文献6

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免疫学杂志
2016年 第1期

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