翻白草提取物对大鼠高血糖症降糖作用及机制研究

Study the effect and mechanism of potentilla discolor bunge extract on rats with hyperglycemia and hypoglycemic

目的:观察翻白草提取物对链脲佐菌素诱导大鼠高糖血症的作用及机制。方法:用链脲佐菌素诱导大鼠高糖血症后,随机分为模型组、翻白草提取物高、中、低剂量给药组、格列本脲药物对照组和正常对照组。给药一周后,测定血糖、ROS、GSH、GSSG和NADP+/NADPH值。结果:经翻白草提取物作用1周后,大鼠血糖和血浆中ROS、GSH等指标均显著低于模型组(P<0.05)。结论:翻白草提取物对糖尿病大鼠具有保护作用,其作用机制与改变糖尿病大鼠体内自身的抗氧化能力,发挥抗氧化应激作用有关。

Objective： To investigate the hypoglycemic effects of extract of potentilla discolor bunge on experimental diabetes in rats induced by STZ. Methods： Hyperglycemia rats model was induced by STZ, and randomly divided into model group, PDB extract high, medium and low dose group, Glibenclamide group and normal control group. Administrated with a week, plasma glucose, ROS,GSH, GSSG and NADP＋/NADPH ratio were detected. Results： Blood glucose and plasma in rats ROS, GSH were significantly decrease with the PDB extract for a week（P〈0.05）. Conclusion： the PDB extract has a protective effect on diabetic rats induced by STZ, the mechanism was related to the change of diabetic rats of the antioxidant capacity and oxidative stress