单侧感音神经性听力损伤患者的失匹配负波小波时频分析

The Wavelet Time-frequency Analysis of Mismatch Negativity in Unilateral Sensorineural Hearing Loss Subjects

目前,对失匹配负波（MMN）的研究主要集中在时域上观察负波的波形与潜伏期。本研究的目的在于利用小波时频变换对神经认知功能的结构及强度进行分析,以此作为鉴别听力损伤后中枢反应的标志。利用128导联电极记录左侧感音神经性听力损伤人群和听力正常人群的MMN,经过小波时频分析,发现MMN波段能量主要集中在低频段（0~4Hz）,分别统计计算两组人的MMN在低频段的小波功率谱,结果表明,正常人与听力受损患者的小波功率谱值存在显著性差异,可见,这种与功能性神经元网络激活相关的时频小波变换能作为特定神经认知功能的判断工具。

At present, the analysis of mismatch negativity （MMN） mostly focuses on its waveform and latency. The aim of this study was to use wavelet transform to analyze MMN and further investigate structural change and functional reaction of the central after hearing loss. The MMN responses were measured between sensorineural hearing loss and control normal hearing population by using a 128-Channel Dense Array EEG System. After wavelet time-frequency transformed, results showed that most energy of MMN concentrate in lower frequency band （0-4 Hz） and in this frequency band, the wavelet power of normal hearing group was significantly larger than that of hearing loss group. It indicated MMN wavelet time-frequency analysis can provide evidence for judging normal hearing persons and hearing loss persons referring to their capability of neural cognitive function.