摘要
目的观察给予高脂饮食对大鼠生精功能的影响。方法健康成年雄性SD大鼠20只随机分为正常对照组和高脂饮食模型组。正常对照组给予正常饮食喂养,高脂饮食模型组大鼠给予高脂饮食喂养,8周后观察其生精功能的变化。结果与正常组大鼠相比,高脂饮食组大鼠的睾丸重量/体重下降,组织学分析显示睾丸生精小管直径、生精细胞计数、间质细胞计数均下降,血清性激素水平明显异常。同时,高脂饮食组大鼠睾丸凋亡增强。结论高脂饮食可诱导大鼠生精功能障碍。
Objective To investigate the effects of high-fat diet on spermatogenesis function in male rats. Methods Twenty adult male rats were randomly divided into control group and high-fat diet （HFD） group. Rats in control group were given add libitum feeding and rats in HFD group were given high-fat diet. Permatogenesis function was measured 8 weeks after treatments. Results Rats in HFD group had decreased testis weight/body weight and abnormal serum sex hormone levels. Histological analysis showed that the diameter of seminiferous tubules, spermatogenetic cells and interstitial cells in the testis were reduced. Meanwhile, apoptosis of testicular cells was increased after HFD treatment. Conclusion High-fat diet induces spermatogenesis dysfunction in male rats.
出处
《医学研究杂志》
2015年第12期88-91,共4页
Journal of Medical Research
关键词
高脂饮食
生精障碍
凋亡
High - fat diet
Spermatogenesis dysfunction
Apoptosis
