瑞替普酶与尿激酶在急性心肌梗死溶栓中的疗效分析

Curative effect analysis of reteplase and urokinase in thrombolysis after acute myocardial infraction

目的比较瑞替普酶(reteplase,r-PA)和尿激酶(Urokinase,UK)对急性心肌梗死(Acute Myocardial Infarction,AMI)溶栓的治疗效果。方法回顾性分析辽阳市中心医院312例接受溶栓治疗的AMI患者临床资料,分成r-PA组和UK组,统计两组的血管开通率、开通时间和出血发生率。结果 r-PA组血管总开通率为81.76%,UK组总开通率为52.82%,且r-PA发病时间<3 h溶栓后血管开通率高于发病时间>3 h组,r-PA组血管开通时间(1.1±0.47)h快于UK组(1.97±0.52)h。以上3组数据相比较差异均具有统计学意义(P<0.05)。r-PA组和UK组出血发生率比较差异无统计学意义(P>0.05)。结论 r-PA溶栓疗效优于UK。

Objective To compare the treatment effect between reteplase（r-PA） and urokinase（UK） in treating throm- bolysis after acute myocardial infraction （AMI）. Methods The clinical data of 312 patients with AMI at our hospital undergoing thrombolytic therapy were retrospectively analyzed.All cases were divided into r-PA group and UK group. Reperfusion rate of blood vessel, reperfusion time of blood vessel and morbidity of hemorrhage were recorded.Results The total reperfusion rate of blood vessel in the r-PA group was 81.76% and 52.82% in the UK group respectively. The reperfusion rate of blood vessel within 3 hours after the onset of AMI was significantly higher than that over 3 hours after the onset of AMI in the r-PA group.The reperfusion time of blood vessel in the r-PA group was（1.1 ＋ 0.47） hours, which was faster than（1.97 ＋_ 0.52） hours in the UK group.The differences of the three pairs of data had statistical sig- nificance（P〈0.05）.The differences of hemorrhage morbidity between the r-PA group and the UK group were not of statistical significance（P〉 0.05）.Conclusion r-PA is more effective than UK in treating thrombolysis after AMI.