Meta分析评价全景片在口腔癌下颌骨侵犯中的诊断效能

Meta-analysis of pantomography for the diagnosis of mandibular invasion caused by oral cancers

目的评价全景片作为筛查口腔癌下颌骨侵犯的诊断效能。方法根据预先设定的检索式对MEDLINE、荷兰医学文摘、MEDION和中国生物医学文献数据库等7个数据库进行电子检索,检索时间截至2014年10月25日;同时进行手动检索。2位评价者独立使用QUADAS-2评价纳入研究的方法学质量并进行数据提取。运用Meta Disc 1.4软件进行Meta分析。结果共纳入12篇研究,涉及患者528名。7篇为前瞻性研究,2篇有高偏倚风险,其余偏倚风险情况不清。Meta分析结果显示,增强CT在诊断下颌骨侵犯的合并敏感度为0.761,合并特异度为0.828,曲线下面积为0.884,Q*为0.814。结论全景片可以作为口腔癌颌骨侵犯的筛查工具,但其在诊断口腔癌颌骨骨髓侵犯的诊断效能需进一步研究。

Objective This study aimed to assess the diagnostic efficacy of pantomography in the screening of mandibular invasion by oral cancers. Methods Seven electronic databases, including MEDLINE, EMBASE, MEDION, and CBM, were searched electronically on October 25, 2014. Hand-searching was also performed. QUADAS-2 was used by two independent reviewers to assess the methodological quality, and data extraction of included studies was delivered by two reviewers in duplicate. Meta-analysis was conductedvia MetaDisc 1.4. Results A total of 12 studies involving 528 participants were included. Sevenstudies were prospective, 2 had high risk of bias, and the rest had unclear risk of bias. Meta-analysis showed that when screening mandibular invasion, pantomography had a pooled sensitivity of 0.761, pooled specificity of 0.828, area under curve of 0.884, and Q＊ of 0.814. Conclusion Pantomography is a good tool for oral cancer mandibular invasion screening. More studies on mandible medullary invasion diagnosed by pantomography should be conducted.