多发性骨髓瘤化疗后发生急性髓系白血病一例并文献复习

Multiple myeloma after chemotherapy secondary to acute myeloid leukemia：a case report and literature review

多发性骨髓瘤（MM）患者比普通人有更大的几率发生第二肿瘤，且大部分为AML／MDS。男性及诊断多发性骨髓瘤年龄小于60岁的年轻患者比女性及诊断多发性骨髓瘤年龄大于60的患者发生血液学恶性肿瘤的可能性大。MM治疗后继发急性白血病的报道越来越多，但MM患者继发白血病以及其他第二肿瘤的机制及治疗目前尚不清楚。MM患者继发白血病后病情进展迅速，死亡率高，化疗后达完全缓解率低。

Second primary malignancies are more likely to occur in the multiple myeloma patients. Most of them are Acute myeloid leukemia（ AML） or Myelodysplastic syndrome（MDS）. The incidence in male or those multiple myeloma patients who is less than 60 years old are more than female or those multiple myeloma patients who are bigger than 60 years old. In recent years, studies of multiple myeloma secondary to leukemia and other tumors are gradually increasing, but the mechanism and treatment are still unclear. These diseases have the follow- ing characteristics such as progress rapidly, high mortality rate and low complete remission rate after chemotherapy.