脑淀粉样血管病相关炎症反应的研究进展

Progress on Cerebral Amyloid Angiopathy-related Inflammation

脑淀粉样血管病(CAA)是一种与年龄相关的中枢神经系统血管病变,是老年人自发性脑出血的重要原因。CAA相关炎症反应(CAA-I),主要表现为CAA与慢性炎症,过去被认为是CAA相关血管病变的一种,但越来越多的研究发现CAA-I患者的临床背景与CAA患者的临床背景不同,治疗效果较好。目前倾向于认为CAA-1是CAA一种独特的临床病理类型。本文就CAA-I最新的研究进展进行综述。

Cerebral amyloid angiopathy （CAA） is an age-related vascular disease in the central nervous system, which accounts for an important part in intracerebral hemorrhage in the old. Cerebral amyloid angiopathy-related inflammation （CAA-I or CAARI）, which characterizes CAA and chronic inflammation, was regarded as CAA-related vascular pathology before. But more and more researches have suggested that CAA-I patients are different from CAA patients in clinical background, and their treatments have better outcome. Now, it tends to recognize CAA-I as a distinct clinicopathological entity. The latest progress of CAA-I were reviewed.