EBV相关性胃癌研究进展

Research advance of EBV-associated gastric cancers

EB病毒感染与胃癌的发生、发展关系密切。经原位杂交技术证实胃癌细胞EBER阳性者称为EBV相关性胃癌,约占所有胃癌的8.2%。2014年TCGA根据分子表型将胃癌分为四种分子亚型:EBV相关性胃癌、微卫星不稳定型胃癌、基因稳定型胃癌和染色体不稳定型胃癌,开启胃癌靶向治疗新时代。基于EBV相关性胃癌的独特性,本文复习近年发表的相关文献,从流行病学、临床病理表现、发病机制、治疗及预后等方面综述EBV相关性胃癌的研究进展。

Epstein-barr virus infection closely associated with the occurrence and development of gastric cancer. Epstein- barr virus-associated gastric carcinomas accounted for about 8.2% of all gastric cancers, in which EBER positive in cancer cell nucleus was confirmed by the in situ hybridization （ISH）. In 2014 according to the molecular phenotype, TCGA divided gastric carcinomas into four subtypes： EBV-positive; microsatellite instability （MSI）; genomicaUy stable （GS） and chromosomaUy instability （CIN）, which opened the new era of targeted therapies in the gastric carcinomas. Based on the uniqueness of its biological behavior, this paper reviewed the research advances about the epidemiology, clinical manifestation, histopathologic features, pathogenesis, treatment and prognosis of EBV-associated gastric cancers.