吉林省238株耐多药结核分枝杆菌药敏结果分析

Analysis of 238 strains multi-drug resistance mycobacterium tuberculosis in Jilin province

目的获得吉林省耐药结核分枝杆菌耐药本底数据,为耐多药结核病的治疗提供依据。方法依据WHO/IUATLD结核病耐药监测指南,收集耐多药结核菌238株,采用比例法对异烟肼、利福平、乙胺丁醇、链霉素、氧氟沙星、卡那霉素进行药敏试验。结果在238株MDR-TB菌株中,耐S率为73.5%,耐EMB率为42.4%,耐Ofx率为33.2%,耐Km率为17.6%;另外,XDR-TB菌株占12.2%。结论吉林省耐多药结核病现状不容乐观,应提高现代结核病控制策略(DOTS)执行质量,加强实验室对MDR-TB和XDR-TB的检测能力。

Objective To obtain information on MDR-TB international comparability,evaluate the effect of the current TB control strategies. Methods According to WHO / IUATLD TB drug resistance surveillance guideline requirements,stratified cluster sampling method was used for its strain identification and isoniazid（ INH）,rifampicin（ RFP）,ethambutol（ EMB）,streptomycin（ S）,oxyfluoride gatifloxacin（ Ofx）,kanamycin（ Km） drug susceptibility testing. Results 238MDR-TB strains were collected and isolated for analyzing multidrug-resistant mycobacterium tuberculosis,the results were as follows： streptomycin resistance rate was 73. 5%; Ethambutol resistance rate was 42. 4%; Oxyfluoride gatifloxacin resistance rate was 33. 2%. Kanamycin resistance rate was 17. 6%. Besides,XDR-TB strains occupied 12. 2%. Conclusion Tuberculosis resistant to multidrug is higher than that of national average level in Jilin province. It is necessary to enhance the implementing quality of DOTS and improve the laboratory detection ability of MDR-TB and XDR-TB.