双歧杆菌四联活菌片联合茵栀黄治疗新生儿黄疸疗效的评价与分析

Evaluation and analysis of the effect of Bifidobacterium Tetravaccine tablets combined with oral liquid of Yinzhihuang for the treatment of neonatal jaundice

目的:评价与分析双歧杆菌四联活菌片联合茵栀黄治疗新生儿黄疸中临床疗效及安全性。方法:按照随机抽签法将376例产科母婴同室新生儿黄疸分组为对照组与观察组,各188例。对照组采用茵栀黄口服液治疗;观察组于对照组治疗基础上加用双歧杆菌四联活菌片治疗。于治疗前和治疗第1、3、5天检测2组患者血清总胆红素水平,统计2组临床药物起效时间和黄疸消退时间及临床疗效、不良反应。结果:治疗前,2组血清胆红素水平比较(P>0.05);治疗第1、3、5天,2组血清胆红素水平较治疗前均明显下降(P<0.05);但第1天,2组组间比较(P>0.05);第3、5天观察组下降更为明显,与对照组比较,P<0.05。观察组临床药物起效时间和黄疸消退时间分别为(1.1±0.4)d、(3.5±1.6)d与对照组(2.7±0.5)d、(5.2±1.9)d比较,P<0.05。观察组治疗有效率明显高于对照组(P<0.05);2组均未发生明显性不良反应。结论:采用双歧杆菌四联活菌片联合茵栀黄治疗新生儿黄疸,其可明显降低患者血清胆红素,且起效快,加速黄疸消退,具有较高安全性,值得进一步研究。

Objective： To evaluate and analyze clinical curative effect and safety of Bifidobacterium Tetravaccine tablets combined with oral liquid of Yinzhihuang in the treatment of neonatal jaundice Methods： 376 cases of neonatal jaundice in obstetric rooming were randomly divided into the control group and the observation group, with 188 cases in each group. The control group was for Yinzhihuang oral therapy, and the observation group for Bifidobacterium Tetravaccine tablets therapy based on the treatment in the control group. Before and 1、3、5 d after treatment serum total bilirubin level were detected in 2 groups of patients, with statistics of clinical drug onset time, jaundice subsided time and clinical efficacy, adverse reactions. Results： Before treatment, there were no significant differences in serum bilirubin levels between the two groups.（P〈0.05. 1,3,5d after treatment serum bilirubin levels in 2 groups significantly decreased compared with pre-treatment（P〈0.05）. However, 1dafter treatment there were no significant differences between the two groups（P〈0.05）,and for 3,5d serum bilirubin levels in observation group decreased more significantly compared with control group（P〈0.05）. In observe group, the onset of clinical drug group and jaundice time was（1.1±0.4） d,（3.5±1.6） d and for the control group（2.7±0.5） d,（5.2±1.9） d（P〈0.05）. Observed treatment group has significantly higher efficiency than the control group（P〈0.05）. Therewere no obvious adverse reactions in 2 groups. Conclusion： Using Bifidobacterium quadruple combined Yinzhihuang treatment in neonatal jaundice can significantly reduce serum bilirubin of patients and accelerate jaundice, with high security and worthy of further research and extension.