丙戊酸对住院患者生化及血常规指标的影响分析

Effect of valproic on biochemical and routine blood test of hospitalized patients

目的：通过分析住院患者服用丙戊酸后生化及血常规指标变化,探究丙戊酸对患者体内生化指标的影响,为临床安全用药提供依据。方法：利用医院HIS系统提取2008—2013年6年期间曾在北京医院住院且服用过丙戊酸的患者信息,包括基本信息、检验信息和医嘱信息,并对这些信息进行汇总分析。结果：在6年间住院且服用丙戊酸的患者共计893人次（731人）,呈逐年增加的趋势;年龄在10~95岁范围内,且70~79岁居多;入院诊断大多为癫痫并入住神经科。这类患者在住院期间,生化及血常规指标呈异常变化趋势。其中血清白蛋白、红蛋白、红细胞均有不同程度的降低,血钾、钠、氯和钙离子的检验值降低的程度不等;尿素氮和谷草转氨酶升高,而白细胞、尿酸、谷丙转氨酶和淀粉酶的变化可能与其他因素有关。结论：长期服用丙戊酸的患者需密切关注以上生化检验指标的变化。

Objective： In order to provide the references of clinical medication safety, routine blood test and blood biochemical indexes of hospitalized patients administrated with valproic acid were analyzed. Methods： Data of the patients were extracted and analyzed from 2008 to 2013 in Beijing hospital, including basic information, laboratory indexand prescription information. Results： The hospitalized patients treated with valproic acid increased year by year in the last 6 years and a total of 893 cases（n =731） were found,age from 10 to 95 years and mostly in the range of 70 to 79 year.Most patients were diagnosed with epilepsy and hospitalized in neurology department. During hospitalization period, biochemical and blood indicators of such patients showed abnormal trends.Among them, serum albumin, hemoglobin, red blood cells decreasedat different levels, levels of potassium, sodium, chloride and calcium ions also decreased. Urea nitrogen and aspartate aminotransferase increased. However, the change of white blood cells, uric acid, alanine aminotransferase and amylase may be related to other factors. Conclusion： Patients treated with valproic acid need to pay close attention to the changes of the above biochemical tests index.