肺癌根治术后自控静脉地佐辛复合舒芬太尼镇痛对患者T细胞亚群和NK细胞含量的影响

Effects of dezocine combined with sufentanil patient-controlled intravenous analgesia on T cells subsets and NK cells contents of lung cancer patients

目的探讨肺癌根治术后自控静脉地佐辛复合舒芬太尼镇痛对患者T细胞亚群和NK细胞含量的影响。方法选取2012年4月至2014年6月期间在我院接受肺癌根治术的130例患者,以随机数字表法将其分为两组,观察组患者接受地佐辛复合舒芬太尼镇痛,对照组患者接受舒芬太尼镇痛。比较两组患者的T细胞亚群和NK细胞含量、CD4+T细胞亚群及相关细胞因子含量以及血小板活化指标。结果 (1)T细胞亚群和NK细胞含量:观察组患者的CD4+T细胞、NK细胞含量高于对照组,CD8+T细胞含量低于对照组;(2)CD4+T细胞亚群及相关细胞因子含量:观察组患者的辅助性T淋巴细胞1(Th1)细胞含量以及Th1细胞因子水平均高于对照组,Th2细胞含量以及Th2细胞因子水平均低于对照组;(3)血小板活化指标:观察组患者的血浆GMP-140、TXA2含量低于对照组,6-keto-PGF1α含量高于对照组。结论地佐辛复合舒芬太尼术后自控静脉镇痛有助于改善免疫功能、调节Th1和Th2细胞功能、抑制血小板过度激活,是肺癌术后理想的镇痛方案。

Objective To study the effect of dezocine combined with sufentanil patient-controlled intravenous analgesia on T cells subsets and NK cells contents of lung cancer patients. Methods Totally 130 patients with lung cancer received radical operation in our hospital from April 2012 to June 2014 were enrolled and randomly divided into two groups. Observation group received dezocine combined with sufentanil analgesia,control group received sufentanil analgesia. Then T cells subsets and NK cells contents,CD4^＋T lymphocyte subsets and related cytokines content,platelet activation markers were compared. Results（ 1） T cells subsets and NK cells contents： CD4^＋T cells,NK cells content of observation group were higher than those of control group; CD8^＋T cells content was lower than that of control group;（ 2） CD4^＋T lymphocyte subsets and related cytokines： Th1 cell content and Th1 cytokine levels of observation were higher than those of control group; Th2 cell content and Th2 cytokine levels were lower than those of control group;（ 3） platelet activation markers： plasma GMP-140,TXA2 content of observation group were lower than those of control group;6-keto-PGF1 content was higher than that of control group. Conclusion Dezocine combined with sufentanil patient-controlled intravenous analgesia is helpful to improve immune function,regulate Th1 and Th2 cell function,inhibit excessive platelet activation; it is an ideal analgesic regime after lung cancer radical operation.