酒精中毒致精神障碍患者脑内神经递质功能研究

Function of neurotransmitters in patients with mental disorders induced by alcoholism

目的利用脑涨落图仪检测酒精中毒所致精神障碍患者脑内多种神经递质功能,探讨酒精中毒所致精神障碍的发病机制。方法筛选符合《中国精神障碍分类及诊断标准(第3版)》(CCMD-3)酒精所致精神障碍的诊断标准的患者为实验组,健康人员为正常对照组,对两组人员均进行脑涨落图仪检测,比较分析两组人员的检测结果。结果与正常组对比,实验组的9种神经递质功率均降低,差异有统计学意义(P<0.05)。实验组的NE相对功率显著低于对照组(P<0.05)。实验组的全脑总功率、运动指数和血管舒缩指数均显著低于对照组(P<0.05)。结论酒精中毒所致精神障碍患者脑内多种神经递质功能降低,尤其是NE功能降低更为明显,同时还有脑血管舒缩功能障碍。脑涨落图仪能够检测分析脑内神经递质的功能和脑神经细胞的供血情况,对研究酒精中毒所致精神障碍发病机制有帮助。

Objective To investigate the function of neurotransmitters in patients with mental disorders induced by alcoholism using the encephalofluctuograph（ EFG）,and to explore the pathogenesis of mental disorders induced by alcoholism. Methods The patients who met the diagnostic criteria for mental disorders induced by alcoholism in Chinese Classification of Mental Disorders（ 3rd version）（ CCMD-3） were enrolled as the study group,and healthy subjects were enrolled as the normal control group. EFG examination was performed for both groups and the results were compared between the two groups. Results Compared with the normal control group,the study group had significantly decreased powers of 9 neurotransmitters（ P〈0. 05）,as well as a significantly decreased relative power of norepinephrine（ NE）（ P〈0. 05）;compared with the normal control group,the study group also had significantly reduced total brain power,motor index,and vasomotor index（ P〈0.05）. Conclusions The powers of neurotransmitters decline in patients with mental diseases induced by alcoholism,especially the decreased power of NE. Such patients may also have vasomotor dysfunction. EFG can analyze the function of neurotransmitters and blood supply in brain neural cells and helps the research on the pathogenesis of mental diseases induced by alcoholism.