基因的异常甲基化在胰腺癌发生发展中作用的研究进展

Abnormal methylation in pancreatic cancer

胰腺癌是侵袭性最高的恶性肿瘤之一,其恶性程度高,预后极差,通常在诊断同时已伴有局部侵袭或者远处转移的症状,失去了进行有效手术切除的机会.其较高的病死率和逐步上升的发病率迫使我们对其发病机制进行更为深入的探索,以达到早诊早治的目的.表观遗传学改变在恶性肿瘤发生发展过程中起着重要作用,其中基因的异常甲基化改变便是表观遗传学理论的重要组成部分,本文探讨胰腺癌发病过程中涉及到多个基因的异常甲基化改变,旨在为胰腺癌的早期诊断及治疗提供新的思路.

Pancreatic cancer is one of the most aggressivemalignancies in the world and has a poor prognosis. Since most cases have already had local invasion or distant metastasis at diagnosis, they usually lost the opportunity for effective surgical resection. Thus, early detection and treatment are of great clinical significance for reducing mortality. Epigenetic c h a n g e s p l a y a n i m p o r t a n t r o l e i n t h e occurrence of cancers. Abnormal methylation is an important part of epigenetic theory. Here we discuss abnormal methylation of multiple genes in pancreatic cancer, with an aim to find methods of early diagnosis and treatment for this devastating disease.