乙肝相关性肝细胞癌患者的预防性抗病毒效果

The effect of prophylactic antiviral therapy on HBV-related hepatocellular carcinoma

目的 探讨接受肝动脉化疗栓塞（TACE）术的乙肝相关性肝细胞癌患者的预防性抗病毒效果,分析患者抗病毒对患者术后复发、生存率的影响.方法 选取52例乙肝相关性肝细胞癌患者为研究对象,随机分成观察组和对照组两组,对照组采取常规支持对症治疗,观察组在对照组治疗基础上加用TACE联合抗病毒治疗,对比两组血清ALT、Child-Pugh评分、生存率及复发率.结果 治疗6个月后观察组ALT及Child-Pugh评分显著低于对照组（t=5.091,P＜0.05）,随访两年后观察组生存率显著高于对照组（x2=17.148,p＜0.05）,复发率显著低于对照组（x2=9.097,P＜0.05）.结论 TACE联合抗病毒治疗对预防术后复发有较好效果,可抑制HBV病毒复制,同时可降低患者病死率.

Objective To investigate the effect of preventive antiviral therapy on HBV related hepatocellular carcinoma in patients who accept transcatheter arterial chenoembolization （TACE）, including the influence on recurrence and post-operative survival rate.Methods Fifty two patients of HBV associated hepatocellular carcinoma were selected as the research objects.They were randomly divided into observation group and control group.The control group received conventional symptomatic treatment, and the observation group received the combined treatment of TACE with antiviral therapy in addition to the same treatment as the control group.The serum ALT, Child-Pugh score, survival rate and recurrence rate in both groups were compared.Results After 6 months of treatment, ALT and Child-Pugh scores in observation group were significantly lower than those of the control group （t =5.091, P 〈 0.05）.After 2 years of follow-up, the survival rate in the observation group was significantly higher than the control group （x2 =17.148, P 〈0.05）, and the recurrence rate was significantly lower than the control group （x2 =9.097, P 〈 0.05）.Conclusions TACE combined with antiviral therapy has positive effects on preventing post-operative recurrence.It can inhibit the replication of the HBV virus, and reduce the mortality of patients.