低纤维蛋白原血症患者的临床特点分析

Analysis of Clinical Characteristics of low Fibrinogen of Patients

目的探讨患者纤维蛋白原(Fbg)降低的原因,临床特点和预后。方法回顾性分析2013年1月1日至2013年12月31日在广东省人民医院的257例Fbg降低(<1.0 g/L)的住院患者的临床资料。结果 1根据住院患者的第一诊断,肿瘤患者占23.35%,心血管疾病患者占22.96%,消化系统性疾病患者占21.79%,感染性疾病患者占12.84%,耳鼻喉病患者占6.61%,血液病患者占3.5%,脑血管疾病患者占3.5%,其他占5.45%。2Fbg下降的原因主要有以下几种:肝脏合成减少、原发性纤溶亢进、继发性纤溶亢进、药物导致。结论血浆低Fbg症原因复杂、预后差,临床应开展合适的检验项目进行准确的实验室鉴别诊断,对疾病的诊治和预后有重要的临床意义。

Objective To explore the causes of decreased fibrinogen with clinical features and prognosis. Methods 257 patients（ Fbg 1. 0 g / l） in Guangdong General Hospital were analyzed by etrospective study methods. Results ① According to the first dianosis of the paitients,Tumor patients account for 23.35%. Cardiovascular disease patients account for 22. 96%. Digestive system disease patients account for 21.79%. Infectious disease patients ccount for 12. 84%. ENT patients account for 6. 61%. Hemopathic patients account for 3. 5%. Cerebrovascular disease patients account for 3. 5%. Others account for 5. 45%. ②The main reasons for the decrease of fibrinogen include decreased production of liver,primary fibrinolysi,secondary increased fibrinolyti activity,drugs cause the decrease of fibrinogen. Conclusion The reasons for decreased fibrinogen are complex and bad prognosis. It＇s relevance for linic diagnosising and treating diseases to carry out the appropriate test items.