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P2X受体的研究进展 被引量:6

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摘要 P2受体是一类与细胞外核苷酸(如ATP、ADP等)相结合的细胞膜受体,这类受体分列为配体门控离子通道受体P2X和G蛋白耦联受体P2Y两大家族,其中P2X受体分为7个亚型(P2X1-7)。P2X1、P2X2最初是由大鼠嗜铬细胞及输精管中克隆得来,在随后的研究中,人们通过筛选组织文库、PCR等方法成功克隆了人类P2X受体。该受体是以ATP为配体的离子门控通道,Na+、K+、Ca2+等可以从中渗透。P2X受体同源性为26%~47%,其结构上类似钾内向整流通道和表皮钠离子通道。
出处 《华中科技大学学报(医学版)》 CAS CSCD 北大核心 2015年第6期741-744,共4页 Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
基金 国家自然科学基金青年基金资助项目(No.81201006) 武汉市卫计委临床医学科研资助项目(No.WX14A09)
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