妊娠早中期妇女25-羟基维生素D水平的研究

Situation of 25-hydroxy Vitamin D deficiency in the first and second trimester of pregnant women

目的了解妊娠早中期妇女25-羟基维生素D[25-(OH)D]水平缺乏情况。方法选取2014年10月至12月在南京市鼓楼区妇幼保健所进行产前保健的孕妇337例,按不同孕周分为妊娠早期和妊娠中期,采用酶联免疫吸附法检测血清25-(OH)D水平。结果 337例妊娠早中期孕妇血清25-(OH)D水平为(42.60±13.84)nmol/L,其中妊娠早期25-(OH)D水平为(35.70±10.93)nmol/L,妊娠中期25-(OH)D水平为(46.40±14.35)nmol/L。妊娠早期与妊娠中期25-(OH)D水平比较差异有统计学意义(t=5.576,P<0.01)。妊娠早期有76.03%的孕妇25-(OH)D缺乏,23.14%的孕妇25-(OH)D不足;妊娠中期有65.28%的孕妇25-(OH)D缺乏,22.69%的孕妇25-(OH)D不足。妊娠早期25-(OH)D缺乏率高于妊娠中期(P<0.05)。结论妊娠早期25-(OH)D水平低于妊娠中期。临床应根据不同孕期对25-(OH)D缺乏或不足的孕妇进行相应的指导,合理补充维生素D。

Objective To survey 25-hydroxy Vitamin D[25-（ OH） D] deficiency status in the first and second trimester pregnant women. Methods A total of 337 pregnant women received antenatal care in maternal and child health institute of Gulou district of Nanjing city from October 2014 to December 2014 were enrolled in this study. They were divided into first trimester pregnancy group and second trimester pregnancy group according to different gestational weeks. Serum 25-（ OH） D levels were measured by enzyme-linked immunosorbent assay（ ELISA）. Results The general level of serum 25-（ OH） D in 337 pregnant women was（ 42. 60 ± 13. 84） nmol / L,and the serum 25-（ OH） D level in first trimester pregnancy group was significantly lower than that in second trimester pregnancy group[（ 35. 70 ± 10. 93） nmol / L vs（ 46. 40 ± 14. 35） nmol / L,P 0. 01]. In first trimester pregnancy group,there were deficiency and insufficiency in 76. 03% women and 23. 14%women,respectively; in second trimester pregnancy group,there were deficiency and insufficiency in 65. 28% women and22. 69% women,respectively. The 25-（ OH） D deficiency rate in first trimester was higher than that in second trimester.Conclusions The serum 25-（ OH） D level in first trimester pregnancy women was lower than that in second trimester pregnancy women. For the women of different pregnancy stage with deficiency or insufficiency of 25-（ OH） D,the corresponding guidance should be given for reasonable supplement of 25-（ OH） D.